205366-79-6Relevant academic research and scientific papers
Fluoro-substitution diphenylethane derivative and preparation method and application thereof
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, (2019/12/25)
The invention relates to a fluoro-substitution diphenylethane derivative. The fluoro-substitution diphenylethane derivative is characterized in that the structure of the fluoro-substitution diphenylethane derivative is shown as the general formula (I) (pl
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones
Ducki, Sylvie,Mackenzie, Grant,Greedy, Ben,Armitage, Simon,Chabert, Jeremie Fournier Dit,Bennett, Elizabeth,Nettles, Jim,Snyder, James P.,Lawrence, Nicholas J.
experimental part, p. 7711 - 7722 (2010/03/04)
Tubulin is an important molecular target in cancer chemotherapy. Antimitotic agents able to bind to the protein are currently under study, commonly used in the clinic to treat a variety of cancers and/or exploited as probes to investigate the protein's st
Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
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, (2008/06/13)
Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
Synthesis of conformationary restricted combretastatins
Shirai, Ryuichi,Okabe, Takuo,Iwasaki, Shigeo
, p. 145 - 148 (2007/10/03)
A series of conformationary restricted heterocyclic combretastatin analogs have been synthesized and their inhibitory activity of microtubule assembly was evaluated. (45,55)-4-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3-dioxolane showed moderate anti
