2054-72-0

Basic information

• Product Name: 2-(1H-INDOL-3-YL)-N-METHYL-2-OXOACETAMIDE
• Synonyms: 2-(1H-INDOL-3-YL)-N-METHYL-2-OXOACETAMIDE
• CAS NO: 2054-72-0
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Mol File: 2054-72-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.297g/cm³
• Refractive Index: 1.649
• CAS DataBase Reference: 2-(1H-INDOL-3-YL)-N-METHYL-2-OXOACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-INDOL-3-YL)-N-METHYL-2-OXOACETAMIDE(2054-72-0)
• EPA Substance Registry System: 2-(1H-INDOL-3-YL)-N-METHYL-2-OXOACETAMIDE(2054-72-0)

Safety Data

• Hazardous Substances Data: 2054-72-0(Hazardous Substances Data)

Usage

Molecular structure

Contains a methyl group and an oxoacetamide group attached to an indol-3-yl ring

Usage

Commonly used in medicinal chemistry and pharmacology research as a building block for the synthesis of bioactive compounds and drug candidates

Potential

Has shown potential as a scaffold for the development of new drugs targeting various biological pathways

Unique structure

Valuable tool for drug discovery and development due to its pharmacological properties

InChI:InChI=1/C11H10N2O2/c1-12-11(15)10(14)8-6-13-9-5-3-2-4-7(8)9/h2-6,13H,1H3,(H,12,15)

Upstream product

• 120-72-9 indole 
• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 74-89-5 methylamine 

Downstream Products

• 61-49-4 [2-(1H-indol-3-yl)-ethyl]-methylamine 
• 55654-84-7 2-methylamino-1-(1-methyl-indol-3-yl)-ethanol 
• 209169-05-1 N-Methyl-6-bromotryptamine 

Relevant articles and documents

Use of novel haptens in the production of antibodies for the detection of tryptamines

Tryptamines are a group of hallucinogenic drugs whose detection in body fluids could be simplified by immunochemical assay kits. Antibodies for these assays are obtained by the immunization of laboratory animals with conjugates of a hapten similar to the target analyte and a suitable protein. Therefore we synthesized novel haptens derived from tryptamine-based drugs, with N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and N,N-diisopropyltryptamine (DiPT) selected as the target analytes. Their structures were modified with a short linker ended with a carboxylic group. The haptens were conjugated with bovine serum albumin (BSA) and rabbits were immunized with the conjugates. The obtained polyclonal antibodies showed good reactivity and the LOD of the constructed ELISAs was in the range 0.006-0.254 ng mL-1. Thus, they are suitable for the development of immunochemical assay kits.