20542-08-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperazineethanol,4-(2-aminoethyl)-(7CI,8CI,9CI) is used as a key intermediate in the synthesis of tetrahydro-imidazoquinoline carboxylates for their potential application as CBP/p300 inhibitors. These inhibitors are being explored for their therapeutic uses in treating various diseases by modulating the activity of CBP/p300 proteins, which play a crucial role in cellular processes and are implicated in several pathological conditions.

Upstream product

• 6820-92-4 2-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione 
• 103-76-4 1-(2-hydroxyethyl)piperazine 

Relevant academic research and scientific papers

Synthesis and DNA cleavage activity of piperazine containing guanidinoethyl and hydroxyethyl side arms

According to active groups synergetic catalysis principle, a novel phosphodiester receptor 1-(N-guanidinoethyl)-4-(N-hydroxyethyl)-piperazidine hydrochloride was firstly synthesized and the preliminary studies of its DNA cleavage activity. It is characterized and confirmed by methods as 1H NMR and 13C NMR. A couple hardness with softness piperazidine is designed to connect guanidinium group and hydroxyl group; The reserch was showed that the best cleaving conditions was 7.2 in pH; Cleaving DNA by the compound reaction was oxidation process that were proved through the free radicals quenches experiments; The compound can cleaved the pUC 19 DNA by phospholipid transferance was proved by BDNPP. A novel DNA cleavage activity of artificial small organic molecule receptor 1-(N-guanidinoethyl)-4-(N- hydroxyethyl)piperazine hydrochloride containing the electrophilic activation guanidinoethyl and the nucleophilic hydroxyl group side arms was synthesized. The results of pH-dependence indicate pH 7.2 is the optimal pH for DNA cleavage in the presence of 3. Transphosphorylation pathway is the mechanism for the DNA cleavage was proved by BDNPP which is used as the DNA mimics successfully. Copyright

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.

A new class of antimalarial drugs: Derivatives of benzothiopyrans

A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160 - 360 mg/kg against Plasmodium berghei in mice. A few observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.