205442-05-3

Upstream product

• 205441-83-4 N-[(E)-3-(benzyloxymethoxy)methyl-2-butenoyl]glycine 
• 205441-89-0 Methanesulfonic acid (2S,3R)-3-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-2,3-dihydroxy-2-methyl-propyl ester 
• 205441-84-5 2-((E)-3-Benzyloxymethoxy-2-methyl-propenyl)-4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-4H-oxazol-5-one 
• 205441-88-9 4-[(3R,4R,5S)-3,4-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-2-((1R,2S)-1,2,3-trihydroxy-2-methyl-propyl)-4H-oxazol-5-one 
• 205441-90-3 4-[(3R,4R,5S)-3,4-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-2-[(R)-hydroxy-((S)-2-methyl-oxiranyl)-methyl]-4H-oxazol-5-one 
• 205441-85-6 (E)-3-{4-[(3R,4R,5S)-3,4-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-2-methyl-propenal 
• 205441-87-8 4-[(3R,4R,5S)-3,4-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-2-((E)-3-hydroxy-2-methyl-propenyl)-4H-oxazol-5-one 
• 205441-82-3 benzyl N-[(E)-3-(benzyloxymethoxy)methyl-2-butenoyl]glycinate 
• 205441-81-2 (E)-3-(benzyloxymethoxy)methyl-2-butenoic acid 
• 13866-57-4 (E)-methyl 4-hydroxy-3-methylbut-2-enoate 
• 205442-04-2 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester 
• 205441-77-6 2-[(E)-2-(benzyloxymethoxy)methyl-1-propenyl]-4H-oxazol-5-one 
• 205441-80-1 (E)-4-Benzyloxymethoxy-3-methyl-but-2-enoic acid methyl ester 

Relevant academic research and scientific papers

A stereoselective synthesis of 4-O-methyl-13-desacetyl-12,13-di-o-benzylcarzinophilin

The title synthesis was achieved by the synthetic scheme featuring the following four key steps: i) coupling of the methyl thioimidate with the 2-oxazolin-5-one (5+6→13), ii) construction of the C17-C21 functionality by the use of Sharpless asymmetric dih