205526-45-0

Basic information

• Product Name: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine
• Synonyms: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine
• CAS NO: 205526-45-0
• Molecular Weight: 405.494
• Mol File: 205526-45-0.mol

Chemical Properties

• CAS DataBase Reference: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine(205526-45-0)
• EPA Substance Registry System: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine(205526-45-0)

Safety Data

• Hazardous Substances Data: 205526-45-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 204845-22-7 (R)-N-2,4,6-trimethoxybenzylphenylglycinol 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 

Downstream Products

• 205526-46-1 (1S,1'R)-1-[N-(2,4,6-trimethoxybenzyl)-N-2'-hydroxy-1'-phenylethylamino]-5,5-ethylenedioxy-1-phenylpentane 
• 38047-66-4 (2R,6S)-2,6-diphenylpiperidine 
• 205526-49-4 (2S,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine 
• 205526-48-3 (2S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-phenylpiperidine 
• 205526-47-2 (2R,9S)-2,9-diphenyl-1-aza-4-oxabicyclo[4.3.0]nonane 

Relevant articles and documents

Stereocontrolled addition of grignard reagents to chiral 1,3-oxazolidines having N-methoxybenzyl groups : Effect of N-substituent in diastereoselectivity

Chiral 1,3-oxazolidines having various N-methoxybenzyl groups were synthesized from (R)-phenylglycinol in three steps. The reactions of chiral 1,3-oxazolidines with Grignard reagents proceeded gently to give the corresponding chiral amines in quantitative yield and high diastereoselectivity. The best results regarding diastereoselectivity were achieved using a chiral 1,3-oxazolidine having N-2,4,6-trimethoxybenzyl moiety. These nitrogen functional groups could be easily removed from the chiral amines using TFA.

Facile diastereoselective reactions of chiral 1,3-oxazolidines with grignard reagents; asymmetric syntheses of 2-substituted and 2,6-disubstituted piperidines

(S)- and (R)-2-Phenylpiperidines, (S)- and (R)-2-methylpiperidines, meso- and (2R, 6R)-2,6-diphenylpiperidines, and meso- and (25, 65)-2,6-dimethylpiperidines were synthesized asymmetrically starting from the diastereoselective addition of Grignard reagents to chiral 1,3-oxazolidines, converting of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives as pivotal intermediates.