749230-22-6

Basic information

• Product Name: 1,2-Difluoro-4-methoxymethoxy-benzene
• Synonyms: 1,2-Difluoro-4-methoxymethoxy-benzene
• CAS NO: 749230-22-6
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.1447264
• Mol File: 749230-22-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Difluoro-4-methoxymethoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Difluoro-4-methoxymethoxy-benzene(749230-22-6)
• EPA Substance Registry System: 1,2-Difluoro-4-methoxymethoxy-benzene(749230-22-6)

Safety Data

• Hazardous Substances Data: 749230-22-6(Hazardous Substances Data)

Upstream product

• 2713-33-9 3,4-difluorophenol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1376335-05-5 2-bromo-3,4,difluoro-phenol 
• 1075700-82-1 2,3-Difluoro-6-(methoxymethyloxy)benzyl alcohol 
• 749230-49-7 3-chloro-4,5-difluoro-2-hydroxybenzoic acid 
• 749230-50-0 4-chloro-2,3-difluoro-5-hydroxybenzoic acid 
• 749230-51-1 2,3-difluoro-5-hydroxybenzoic acid 
• 205533-31-9 4,5-difluoro-2-hydroxybenzoic acid 
• 749230-48-6 2-chloro-3,4-difluoro-1-(methoxymethoxy)benzene 

Relevant articles and documents

CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.