205582-88-3

Basic information

• Product Name: METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE
• Synonyms: METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE;3-(Ethoxycarbonyl)-2-methyl-6-(trifluoromethyl)pyridine
• CAS NO: 205582-88-3
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.16
• Mol File: 205582-88-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 209.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.286±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.78±0.22(Predicted)
• CAS DataBase Reference: METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE(205582-88-3)
• EPA Substance Registry System: METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE(205582-88-3)

Safety Data

• Hazardous Substances Data: 205582-88-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-methyl-6-(trifluoromethyl)nicotinate is a chemical compound with the molecular formula C11H9F3N2O2. It is commonly used in the pharmaceutical and agrochemical industries for its potential therapeutic and pesticidal properties. METHYL 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINATE is a derivative of nicotinic acid and contains a methyl group and a trifluoromethyl group, which contributes to its unique chemical properties. Methyl 2-methyl-6-(trifluoromethyl)nicotinate has been studied for its potential use as an antiviral and anti-inflammatory agent, as well as for its insecticidal and fungicidal activities. Additionally, its trifluoromethyl group may enhance its bioactivity and metabolic stability, making it a valuable compound in drug discovery and agricultural applications.

Upstream product

• 120417-45-0 4-amino-1,1,1-trifluoro-3-buten-2-one 
• 105-45-3 acetoacetic acid methyl ester 
• 184848-89-3 4-amino-1,1,1-trifluorobuten-2-one 
• 39971-65-8 bis(((trifluoromethyl)sulfinyl)oxy)zinc 
• 65719-09-7 methyl 2-methylnicotinate 
• 400-36-2 trifluoroacetylacetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 14205-39-1 methyl 3-aminocrotonate 

Downstream Products

• 261635-93-2 2-methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid 
• 917969-46-1 8-bromo-7-(4-chlorophenyl)-2-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 917969-39-2 4-(8-bromo-2-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)benzonitrile 
• 917968-89-9 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-2-methyl-6-(trifluoromethyl)pyridine 1-oxide 
• 917969-50-7 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinoyl chloride 

Relevant articles and documents

Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from 4,4,4-trifluoro-3-aminobutanoates

The invention discloses a method for the preparation of substituted 6-trifluoromethylpyridine-3-carboxylic acid derivatives starting from 4,4,4-trifluoro-3-aminobutanoates and proceeding via enamines and dihydropyridinones.

Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives

The invention discloses a method for the preparation of substituted 6-trifluoromethylpyridine-3-carboxylic acid derivatives starting from 1,1,1-trifluoroacetone or from synthetic equivalents of 1,1,1-trifluoroacetone.

Triazolopyridine cannabinoid receptor 1 antagonists

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.