205652-13-7

Upstream product

• 128781-07-7 5,6,7-trimethoxy-1H-indole-2-carboxylic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 156295-30-6 (S)-3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 156295-31-7 (S)-8-Acetoxymethyl-4-benzyloxy-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 156295-32-8 (S)-4-Benzyloxy-8-hydroxymethyl-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 156295-33-9 (S)-4-Benzyloxy-8-chloromethyl-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 179693-97-1 (S)-8-Chloromethyl-4-hydroxy-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 

Downstream Products

• 154889-68-6 3-methoxycarbonyl-2-methyl-8-O-(4-methyl-1-piperazinylcarbonyl)duocarmycin B2 
• 153925-97-4 3-methoxycarbonyl-2-methylduocarmycin A 

Relevant academic research and scientific papers

Novel syntheses of optically active CC-1065, U-73,975(adozelesin), U-80,244(carzelesin), U-77,779(bizelesin), KW-2189, and DU-86

The title syntheses were achieved by the method featuring oxidative cyclization of the enamino esters [(S)-13 and (S)-24] derived from the 5-aminoindoline [(5)-12], acylation with various structural types of indole-2-carboxylic acids, and formation of cyclopropapyrroloindole moieties.