205677-05-0

Upstream product

• 753-90-2 trifluoroethylamine 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 

Downstream Products

• 558483-95-7 N-(2-bromo-5-methoxybenzyl)-2-methylene-N-(2,2,2-trifluoroethyl)-succinylamide-4-ethyl ester 
• 558483-97-9 N-(2-bromo-5-methoxybenzyl)-N-(2,2,2-trifluoroethyl)acrylamide 

Relevant academic research and scientific papers

Vitronectin receptor antagonists

Compounds having a benzodiazepinyl core structure are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis, angiogenesis, tumor growth and metastasis, atherosclerosis, restenosis and inflammation.

Convenient synthesis of 2-benzazepines via radical cyclization

Synthesis of 2-benzazepines was readily achieved via 7-endo radical cyclization of N-o-bromobenzylitaconamides or N-o-bromobenzylmethacrylamides which were prepared in two steps from commercially available benzaldehydes, amines, and α,β-unsaturated acids.