2057-45-6

Upstream product

• 536-75-4 4-Ethylpyridine 
• 100-42-5 styrene 
• 143097-80-7 2-bromo-4-phenylbutane 
• 768-56-9 4-Phenylbut-1-ene 
• 40949-56-2 N-(p-toluenesulphonylimino)pyridinium ylide 
• 2057-49-0 4-(3-phenylpropyl)pyridine 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 103-63-9 1-phenyl-2-bromoethane 

Relevant academic research and scientific papers

Regiodivergent Conversion of Alkenes to Branched or Linear Alkylpyridines

Herein we report a practical protocol for the visible-light-induced regiodivergent radical hydropyridylation of unactivated alkenes using pyridinium salts. This approach provides a unified synthetic platform to control the regioselectivity of the synthesis of linear or branched C4-alkylated pyridines. A remarkable selectivity switch from the anti-Markovnikov to the Markovnikov product can be achieved by the addition of tetrabutylammonium bromide. The versatility of this protocol is further demonstrated based on the late-stage functionalization in pharmaceuticals.

C(sp3)-H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling

The “magic methyl” effect describes the change in potency, selectivity, and/or metabolic stability of a drug candidate associated with addition of a single methyl group. We report a synthetic method that enables direct methylation of C(sp3)-H bonds in diverse drug-like molecules and pharmaceutical building blocks. Visible light-initiated triplet energy transfer promotes homolysis of the O-O bond in di-tert-butyl or dicumyl peroxide under mild conditions. The resulting alkoxyl radicals undergo divergent reactivity, either hydrogen-atom transfer from a substrate C-H bond or generation of a methyl radical via b-methyl scission. The relative rates of these steps may be tuned by varying the reaction conditions or peroxide substituents to optimize the yield of methylated product arising from nickel-mediated cross-coupling of substrate and methyl radicals.

Potassium Amide-Catalyzed Benzylic C?H Bond Addition of Alkylpyridines to Styrenes

The benzylic functionalization of alkylpyridines is an important pathway for pyridine derivatives synthesis. The reaction partners, however, were mostly limited to highly reactive polar electrophiles. Herein, we report a potassium amide-catalyzed selective benzylic C?H bond addition of alkylpyridines to styrenes. Potassium bis(trimethylsilyl)amide (KHMDS), a readily available Br?nsted base, showed excellent catalytic activity and chemoselectivity. A series of alkylpyridine derivatives, including benzylic quaternary carbon substituted pyridines, were obtained in good to high yield. Preliminary mechanistic studies revealed that the deprotonation equilibrium is probably responsible for the excellent selectivity.

Synthesis and antifungal activity of novel aza-D-homosteroids, hydroisoquinolines, pyridines and dihydropyridines

A series of novel aza-D-homosteroids and their hydroisoquinoline precursors were synthesized and tested for antifungal activity against a variety of Candida strains and also Aspergillus species. A number of 4-substituted pyridines and tetrahydropyridines

Pyridine derivatives and insecticide and miticide comprising said derivatives

A pyridine compound of the formula STR1 wherein X is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms or a haloalkoxyl group having 1 to 4 carbon atoms, n is 1 to 5, and when n is 2 or more, Xs may be identical to or different from each other, A is an alkyl residue or alkene residue in which a portion connecting the aryl group with the 4-position of the pyridyl group has 3 to 8 carbon atoms, or an alkapolyene residue in which said portion has 4 to 8 carbon atoms and 2 to 4 double bonds; the alkyl residue, alkene residue, and alkapolyene residue may have an alkyl side chain having 1 to 4 carbon atoms, an alkylidene side chain having 1 to 4 carbon atoms or 1 to 16 halogen atoms, and when there are 2 or more side chains, the side chains may be identical to or different from each other, and R1 and R2 are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or salts thereof. The pyridine compounds and salts thereof exhibit a strong insecticidal and miticidal activity and are low in residuality and accumulativity and are thus useful as insecticides and miticides for the control of pests in agriculture and horticulture.