20574-99-6

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-METHYLPHENYL)-1-BUTENE is used as a chemical intermediate for the production of various pharmaceuticals, contributing to the development of new medications and enhancing the synthesis of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(4-METHYLPHENYL)-1-BUTENE is utilized as a building block in the creation of agrochemicals, playing a role in the development of pesticides and other agricultural products to improve crop protection and yield.
Used in Dye Industry:
4-(4-METHYLPHENYL)-1-BUTENE is employed as an intermediate in the synthesis of dyes, contributing to the production of a variety of colorants used in different industries, including textiles, plastics, and printing.
Used in Polymer and Resin Synthesis:
4-(4-METHYLPHENYL)-1-BUTENE is also used as a building block in the synthesis of polymers and resins, which are essential in the manufacturing of various materials and products across multiple industries.
Safety Note:
Given its flammable nature and potential hazards if ingested or inhaled, 4-(4-METHYLPHENYL)-1-BUTENE requires careful handling and proper storage to ensure safety during its use in these applications.

InChI:InChI=1/C11H14/c1-3-4-5-11-8-6-10(2)7-9-11/h3,6-9H,1,4-5H2,2H3

Upstream product

• 89980-67-6 p-methylbenzylmagnesium bromide 
• 106-95-6 allyl bromide 
• 106-99-0 buta-1,3-diene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 104-81-4 4-Methylbenzyl bromide 
• 1730-25-2 allylmagnesium bromide 
• 5720-05-8 4-methylphenylboronic acid 
• 589-18-4 4-Methylbenzyl alcohol 
• 24850-33-7 allyltributylstanane 
• 4519-36-2 (4-methylbenzyl)-trimethylammonium chloride 
• 5406-39-3 3-(4-methylphenyl)propanol 
• 1505-50-6 3-(4-Methylphenyl)propanoic acid 
• 5406-12-2 3-(4-methylphenyl)propionaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 4023-84-1 4-(p-tolyl)-3-buten-2-one 
• 91130-33-5 1-but-1-enyl-4-methyl-benzene 
• 1595-05-7 p-butyltoluene 
• 172840-98-1 1-(but-2-en-1-yl)-4-methylbenzene 
• 54372-77-9 (E)-1-(but-1-en-1-yl)-4-methylbenzene 
• 21003-53-2 trans-1-(but-2-en-1-yl)-4-methylbenzene 
• 79211-50-0 cis-1-(but-2-en-1-yl)-4-methylbenzene 
• 74591-95-0 2-((E)-4-p-Tolyl-but-3-enyl)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Synthesis and structure-property relationships of polypropylene-g- poly(ethylene-co-1-butene) graft copolymers with well-defined long chain branched molecular structures

A series of polypropylene-g-poly(ethylene-co-1-butene) (PP-g-EBR) graft copolymers with well-defined long chain branched (LCB) molecular structures were synthesized via the combination of coordination polymerization and anionic polymerization. The structu

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

Pd-catalyzed C4-Dearomative Allylation of Benzyl Ammoniums with Allyltributylstannane

A dearomative C4-allylation of benzyl ammoniums with allyltributylstannane by a palladium catalysis is described. A triarylphosphine-ligated palladium catalyst, which is capable of cleaving benzylic CN bonds, realized facile dearomative reactions with C4 selectivity. Combined with precedented C2- A nd C3-selective functionalizations of benzyl amine derivatives, the present reaction can provide a new synthetic option for the synthesis of multi-substituted alicyclic compounds as well as aromatic compounds.

Efficient preparation method of 1-aryl-4-butene compound

The invention belongs to the technical field of fine chemicals and related chemistry, and provides an efficient preparation method of a 1-aryl-4-butene compound. The 1-aryl-4-butene compound can be obtained by taking halogen-containing methyl aromatic hyd

Controllable Isomerization of Alkenes by Dual Visible-Light-Cobalt Catalysis

We report herein that thermodynamic and kinetic isomerization of alkenes can be accomplished by the combination of visible light with Co catalysis. Utilizing Xantphos as the ligand, the most stable isomers are obtained, while isomerizing terminal alkenes over one position can be selectively controlled by using DPEphos as the ligand. The presence of the donor–acceptor dye 4CzIPN accelerates the reaction further. Transformation of exocyclic alkenes into the corresponding endocyclic products could be efficiently realized by using 4CzIPN and Co(acac)2 in the absence of any additional ligands. Spectroscopic and spectroelectrochemical investigations indicate CoI being involved in the generation of a Co hydride, which subsequently adds to alkenes initiating the isomerization.

Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation

Palladium-catalyzed allylic alkylation of nonstabilized carbon nucleophiles is difficult and remains a major challenge. Reported here is a highly chemo- and regioselective direct palladium-catalyzed C-allylation of hydrazones, generated from carbonyls, as a source of umpolung unstabilized alkyl carbanions and surrogates of alkyl organometallic reagents. Contrary to classical allylation techniques, this umpolung reaction utilizes hydrazones prepared not only from aryl aldehydes but also from alkyl aldehydes and ketones as renewable feedstocks. This strategy complements the palladium-catalyzed coupling of unstabilized nucleophiles with allylic electrophiles by providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.

2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL

Compounds of formula (VIII) and compositions for treating disorders related to TRPA1 are described herein.

Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation

We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a NiI/NiIII catalytic cycle.

Monocarboxylation and intramolecular coupling of butenylated arenes via palladium-catalyzed C-H activation process

A novel and practical reaction for the direct intramolecular oxidative coupling of butenylated arenes is reported. With the catalysis of Pd(OAc)2, reactions of various butenylated arenes and carboxylic acids with Selectfluor reagent in CH3CN solution afforded the corresponding monocarboxylation/cyclization products in good yields under mild conditions. This research demonstrated an economic method with the synthesis of 2-tetralyl carboxylic esters, a valuable class of bioactive compounds.

Wacker-type oxidation and dehydrogenation of terminal olefins using molecular oxygen as the sole oxidant without adding ligand

An efficient and economical palladium-catalyzed oxidation system has been identified. The oxidation system, characterized by not adding ligand and using molecular oxygen as the sole oxidant, can realize the Tsuji-Wacker oxidation of terminal olefins and especially styrenes to methyl ketones; in addition, this system can achieve tandem Wacker oxidation-dehydrogenation of terminal olefins to α,β-unsaturated ketones.