20577-36-0Relevant academic research and scientific papers
Alkyne hydroacylation: Switching regioselectivity by tandem ruthenium catalysis
Chen, Qing-An,Cruz, Faben A.,Dong, Vy M.
supporting information, p. 3157 - 3160 (2015/03/30)
By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl vs ethyl substituent on the alkyne. Mechanistic studies suggest that the regioselectivity results from a selective allene formation that is governed by allylic strain.
