20577-46-2Relevant articles and documents
Irreversible Protein Labeling by Paal–Knorr Conjugation
Dasari, Ramesh,La Clair, James J.,Kornienko, Alexander
, p. 1792 - 1796 (2017)
The application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or Diels–Alder cycloadditions have enabled the labeling of specific residues in biomolecules by the attachment of molecules carrying azides, alkynes, or strained alkenes. Although these are fundamental tools, there is a need for the discovery of reactions that can label native proteins. We report herein the adaptation of the Paal–Knorr reaction to label lysine residues in proteins via pyrrole linkages.
4,7-Dioxooctanoic Acid from the Acid Catalysed Reaction of (E)-4-(2-furyl)but-3-enone. Electrochemical Hydrogenation of some Furan Derivatives
Abeysekera, Ajita M.,Amaratunge, Shiyamalie,Grimshaw, James,Jayeweera, Nihal,Senanayake, Gamini
, p. 2021 - 2023 (2007/10/02)
A two phase acidic reaction medium has been developed for the conversion of (E)-4-(2-furyl)but-3-enone into 4,7-dioxooctanoic acid in consistent yields of 50percent with concomitant formation of 15percent polymer.The corresponding ring opening of 1-(2-furyl)-5-methylhex-1-en-3-one proceeds in homogeneous acid solution in very high yield without polymer formation.The two furylalkenones can be reduced electrochemically to the corresponding furylalkylketones in good yields at a lead cathode in the presence of sodium hydrogen carbonate.
SINTESI DELL'EMI-(IDRO)-PIRENOFORINCHETALE DAL 5-METIL-2-FURFURALE
Pirillo, D.,Rescia, G.,Traverso, G.,Paoli, A. De
, p. 324 - 332 (2007/10/02)
The synthesis of hemi-(hydro)-pyrenophorinketale (I) starting from the 5-methyl-2-furfural (III) via the substituted γ-valerolactone (X) is reported.The lactone (XV), α,β-unsaturated analogous of (X), by basic hydrolysis and esterification affords the same ketoester (XII) obtained from (X) by oxidation of the corresponding open hydroxiester.