2058-58-4

Basic information

• Product Name: D-(-)-Asparagine monohydrate
• Synonyms: ASPARAGINE, D-;ASPARAGINE;(D)-ASPARTIC ACID 4-AMIDE;D-ASPARAGINE;(R)-2-AMINOSUCCINIC ACID 4-AMIDE;(R)-2-Aminosuccinamic acid;H-D-Asn-OH·H2O;D-2-Aminosuccinamic acid
• CAS NO: 2058-58-4
• Molecular Formula: C₄H₈N₂O₃
• Molecular Weight: 132.12
• EINECS: 218-163-3
• Product Categories: Amino Acids Derivatives;Amino Acids and Derivatives;Amino Acids
• Mol File: 2058-58-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 280 °C (dec.)(lit.)
• Boiling Point: 438 °C at 760 mmHg
• Flash Point: 218.7 °C
• Appearance: /
• Density: 1.404 g/cm³
• Vapor Pressure: 2.38E-06mmHg at 25°C
• Storage Temp.: Store at 0-5°C
• PKA: 2.17(at 20℃)
• Merck: 13,842
• BRN: 1723526
• CAS DataBase Reference: D-(-)-Asparagine monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: D-(-)-Asparagine monohydrate(2058-58-4)
• EPA Substance Registry System: D-(-)-Asparagine monohydrate(2058-58-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 1
• Hazardous Substances Data: 2058-58-4(Hazardous Substances Data)

Usage

Chemical Properties

crystalline powder

Definition

ChEBI: An optically active form of asparagine having D-configuration.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 35, p. 2994, 1987 DOI: 10.1248/cpb.35.2994

InChI:InChI:1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)

Upstream product

• 108-31-6 maleic anhydride 
• 3130-87-8 ASPARAGINE 
• 101-41-7 benzeneacetic acid methyl ester 
• 43101-48-0 DL-aspartic acid diethyl ester 
• 7664-41-7 ammonia 
• 21860-86-6 aspartic acid 4-ethyl ester 
• 70-47-3 L-asparagine 
• 7732-18-5 water 
• 98490-54-1 optically inactive (3,6-dioxo-piperazine-2,5-diyl)-di-acetic acid diamide 
• 4474-86-6 (R)-4-amino-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoic acid 

Downstream Products

• 117146-35-7 N^α-[(2,4,5-trichloro-phenoxy)-acetyl]-D-asparagine 
• 1783-96-6 (2R)-aspartic acid 
• 636-61-3 D-Malic acid 
• 6293-92-1 N-(2,4-Dichlor-phenoxyacetyl)-D-asparagin 
• 617-45-8 aspartic Acid 
• 122723-93-7 N²-chloroacetyl-D-asparagine 
• 908802-63-1 2-(R)-asparagine 
• 88194-24-5 D,L-succinamopine 
• 97974-51-1 (R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-N¹-[(S)-1-((S)-1-carbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-succinamide 
• 92142-18-2 N-(p-Toluolsulfonyl)-D-asparagin 
• 859235-81-7 MeZ-(R)-Asn-OH 
• 33239-40-6 4-amino-2,4-dioxobutanoic acid 
• 70-47-3 L-asparagine 
• 141779-75-1 D-Asn-L-DAA 

Relevant articles and documents

Pasteur-like resolution of quasi-racemates in solid and gas phases

Isotopomeric quasi-racemates (IQR), i.e., 1:1 mixtures of enantiomers one of which contains an isotopic label, can undergo crystallisation as conglomerates or true quasi-racemates. In the former case, each single crystal contains, predominantly or exclusi

Useful Impurities for Optical Resolutions. 3. An Improved Pasteur-Type Resolution of Conglomerates and a New Empirical Method for Assignment of Absolute Configuration

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Self-Reporting Inhibitors: A Single Crystallization Process To Obtain Two Optically Pure Enantiomers

Collection of two optically pure enantiomers in a single crystallization process can significantly increase the chiral separation efficiency but this is difficult to realize. Now a self-reporting strategy is presented for visualizing the crystallization process by a dyed self-assembled inhibitor made from the copolymers with tri(ethylene glycol)-grafting polymethylsiloxane as the main chain and poly(N6-methacryloyl-l-lysine) as side chains. When applied with seeds together for the fractional crystallization of conglomerates, the inhibitors can label the formation of the secondary crystals and guide the complete separation process of two enantiomers with colorless crystals as the first product and red crystals as the second. This method leads to high optical purity of d/l-Asn?H2O (99.9 % ee for d-crystals and 99.5 % for l-crystals) in a single crystallization process. It requires a small amount of additives and shows excellent recyclability.

SEPARATING AGENT AND MANUFACTURING METHOD THEREOF

An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.