43101-48-0

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl DL-aspartate is used as an intermediate in the synthesis of Aspartic Acid (A788955) related compounds for the development of pharmaceutical products. Its role in the synthesis process is essential for creating new drugs and therapeutic agents that can target specific health conditions and diseases.

InChI:InChI=1/C8H15NO4/c1-3-12-7(10)5-6(9)8(11)13-4-2/h6H,3-5,9H2,1-2H3/t6-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 617-45-8 aspartic Acid 
• 7664-41-7 ammonia 
• 141-05-9 Diethyl maleate 
• 872822-56-5 nitroso-succinic acid diethyl ester 
• 64-19-7 acetic acid 
• 623-91-6 diethyl Fumarate 
• 110-17-8 (2E)-but-2-enedioic acid 
• 131401-52-0 Diethyl 2-(Hydroxyimino)succinate 
• 21860-86-6 aspartic acid 4-ethyl ester 

Downstream Products

• 407-27-2 2-Fluor-bernsteinsaeure-diethylester 
• 1057404-70-2 dl-N-(1,4-dioxo-4-phenylbutyl)aspartic acid diethyl ester 
• 50838-94-3 (2,4-dinitro-phenylhydrazono)-succinic acid diethyl ester 
• 104830-35-5 p-toluenesulfonamidosuccinic acid diethyl ester 
• 862508-85-8 5-[(4-fluorophenyl)methyl]-2,3-pyridinecarboxylic acid 
• 2058-58-4 (R)-Asparagine 
• 70-47-3 L-asparagine 
• 95361-46-9 C₁₄H₁₇NO₄S 
• 71416-69-8 N-(1,2-bisethoxycarbonylethyl)-N'-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalamide 
• 617-45-8 aspartic Acid 
• 111472-02-7 (2-phenyl-1⁽³⁾H-imidazol-4-yl)-acetic acid ethyl ester 
• 13552-87-9 L-aspartic acid diethyl ester 
• 3130-87-8 ASPARAGINE 
• 142784-76-7 diethyl 2-(dibenzylamino)succinate 

Relevant academic research and scientific papers

SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES

This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.

Polymer Particles

A process for covalently binding a tagged protein to a polymer particle comprising: contacting a tagged protein with a chelating agent-polymer particle conjugate wherein said tag comprises at least two histidine residues and at least two lysine residues and said chelating agent is tridentate, tetradentate or pentadentate and comprises at least two carboxyl groups and is coordinated by Co2+ ions, to form particle-chelating agent Co2+ complex: contacting said complex with a carbodiimide; and optionally removing the Co2+ ions.

Enzymatic selective transformations of diethyl fumarate

Candida antarctica lipase selectively catalyses transformations of diethyl fumarate in organic solvents. A range of nitrogen nucleophiles, including ammonia, can be successfully used in these enzymatic reactions, monoamides and monohydrazides being obtained in high to moderate yields. In contrast, diethyl maleate is not an adequate substrate for this enzyme.

Regio- and Chemo-selective Properties of Lipase from Candida cylindracea

Lipase from Candida cylindracea allows discrimination between the two connectively non-equivalent hydroxy groups in primary diols or their esters via acylation-hydrolysis, with high regioselectivity.The same technique is used to distinguish between hydroxy groups of different nature in phenolic compounds.

ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST - II. ESTERS OF N-ACETYL AMINO ACIDS

D-N-Acetyl amino acid esters were obtained via enantioselective hydrolysis of their racemates by use of fermenting yeast.Evidence is given that proteinases are the enzymes involved.

EFFET DE LA CONCENTRATION EN ACIDE FLUORHYDRIQUES DANS LA PYRIDINE SUR LA REGIO-SELECTITE DE LA FLUORATION PAR DEAMINATION D'α-AMINO-ESTERS : SYNTHESES DE COMPOSES CARBOXYLES-β-FLUORES.

Fluorodeamination of α-amino-esters with sodium nitrite in HF-pyridine gives mainly β-fluoro-esters.The molar ratio HF-pyridine is the main parameter for the α-β regioselectivity.