134-46-3Relevant articles and documents
5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy,5- fluorouridine: A membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP)
Farquhar,Chen,Khan
, p. 488 - 495 (1995)
5'-[4-(Pivatoyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5- fluorouridine (1c) was designed as a potential membrane-permeable prodrug of 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP), a putative active metabolite of the antitumor drug 5-fluorouracil
New synthesis and antitumor activity of cyclosalderivatives of 5-fluoro-2′-deoxyuridinemonophosphate
Lorey, Martina,Meier, Chris,De Clercq, Eric,Balzarini, Jan
, p. 789 - 792 (2007/10/03)
An improved synthesis of 5′-cycloSal-FdUMP 3a-g and 3′,5′-bis-cycloSalFdUMP 9a-g as potential prodrugs of FdU 1 is described. In hydrolysis studies, phosphotriesters 3 released FdUMP 2 selectively by a tandem reaction. The biological activity of cycloSal-phosphotriesters 3 and 9 was evaluated in different cell lines. Copyright
Nucleoside conjugates. 8. The preparation of 5-fluoro-2'-deoxyuridine conjugates of corticosteroids
An,West,Hong
, p. 413 - 420 (2007/10/02)
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