205983-74-0Relevant academic research and scientific papers
Compounds for enzyme inhibition
-
Page/Page column 33, (2008/06/13)
One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administer
Novel stereoselective syntheses of the fused benzazepine dopamine D1 antagonist (6as,13br)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5h-benzo[d]naphth[2,1-b] azepin-12-ol (sch 39166): 2. l-homophenylalanine-based syntheses
Draper, Richard W.,Hou, Donald
, p. 186 - 193 (2013/09/08)
Two enantioselective syntheses of the fused benzazepine dopamine D1 antagonist (6aS,13bR)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b] azepin-12-ol (1) are described in which the starting material is (+)-L-homophenylalan
An efficient and enantioselective synthesis of a chiral primary amine
Son, Youngchan,Park, Chihyo,Koh, Jong Sung,Choy, Nakyen,Lee, Chang S.,Choi, Ho-Il,Kim, Sung Chun,Yoon, Heungsik
, p. 3745 - 3746 (2007/10/02)
An efficient and enantioselective method for the preparation of a chiral primary amine has been developed. Starting from N-protected L or D-amino acid the sequence involves coupling with N-methoxy-N-methylamine, acylation, olefination with potassium bis(trimethylsilyl)amide, and hydrogenation.
