20599-34-2

Upstream product

• 20599-29-5 (α-butoxy-benzyl)-dimethyl-amine 
• 106-95-6 allyl bromide 
• 20599-31-9 (Butylsulfanyl-phenyl-methyl)-dimethyl-amine 
• 103-83-3 N,N'-dimethylbenzylamine 
• 100-52-7 benzaldehyde 
• 13880-55-2 N,N,N',N'-tetramethyl-C-phenylmethanediamine 
• 24850-33-7 allyltributylstanane 
• 2622-05-1 allylmagnesium bromide 
• 611-74-5 N,N-dimethylbenzamide 
• 762-72-1 allyl-trimethyl-silane 

Relevant academic research and scientific papers

Method for synthesizing homoallylamine compounds

The invention discloses a method for synthesizing homoallylamine compounds, and belongs to the field of organic synthesis. N,N-acetal compounds represented by formula (I) are used as a substrate, andreact with a nucleophilic reagent allyl silicon compound represented by formula (II) under the activation of a Lewis acid to efficiently prepare the homoallylamine compounds represented by formula (III), and the yield can reach 85%. The method is simple and green, can efficiently obtain the target product, and has very good industrial application prospects.

One-Pot Reductive Allylation of Amides by Using a Combination of Titanium Hydride and an Allylzinc Reagent: Application to a Total Synthesis of (-)-Castoramine

A one-pot direct reductive allylation protocol has been developed for the synthesis of secondary amines by using titanium hydride and an allylzinc reagent. This protocol is applicable to a broad range of substrates, including acyclic amides, benzamides, α,β-unsaturated amides, and lactams. The stereochemical outcome obtained from the reaction with crotylzinc reagent suggested that the allylation reaction proceeds through a six-membered cyclic transition state. A total synthesis of (-)-castoramine was accomplished by following this protocol for the highly stereoselective construction of contiguous stereocenters.

Allylation of n,n-acetal derivatives using allyl tin reagent in the presence of aluminum chloride

Allylation of N,N-acetal derivatives proceeded efficiently using allyl tin regent in the presence of aluminum chloride, giving homoallylamines in good yields. This allylation was applied for N,S-acetals to give the corresponding homoallylamines.

Zinc-mediated allylation and alkylation of aminals in the presence of TMSCl and diisopropylamine

(Chemical Equation Presented) An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, α-bromoacetate, and α-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.

TERTIARY AMINE AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a new tertiary amine and a method for easily producing the tertiary amine in improved yield. SOLUTION: The tertiary amine is expressed by general formula (1) and produced by adding a thioamide expressed by general formula

Tertiary amine and method for producing the same

The present invention relates to a method for easily producing a tertiary amine with high yield. A tertiary amine represented by general formula (1) is produced by adding a metal-containing reagent represented by general formula (6) into a reaction system

Metallation of benzylic amines via amine-borane complexes

Formation of borane complexes of N,N-dimethylbenzylamine, N,N- dimethyl(1-naphthyl)methylamine, N,N-dimethyl(2-naphthyl)methylamine, N- methyltetrahydroisoquinoline and N-methylisoindoline facilitates regioselective metallation of these systems using BuLi, giving intermediate benzylic anions which react with a range of electrophiles to give products in good yield.

Activation of Benzylic Amines Towards Regioselective Metallation by Borane Complex Formation

Formation of borane complexes of N,N-dimethylbenzylamine 4 and N-methyltetrahydroisoquinoline 1 facilitates regioselective metallation of these systems using BuLi, giving benzylic anions which react with a range of electrophiles.