2060-89-1

Usage

Uses

Used in Organic Synthesis:
1,3-Bis(trimethylsilyl)benzene is used as a building block for the synthesis of various organic compounds due to its high reactivity. It serves as a precursor in the creation of pharmaceuticals, agrochemicals, and specialty chemicals, contributing to the development of new and innovative products in these industries.
Used as a Protecting Group in Organic Chemistry:
In the field of organic chemistry, 1,3-bis(trimethylsilyl)benzene is employed as a protecting group for alcohols and phenols. This application is crucial for preventing unwanted side reactions during the synthesis process, ensuring the successful production of the desired compounds.
Used in Pharmaceutical Industry:
1,3-Bis(trimethylsilyl)benzene is used as a key intermediate in the synthesis of pharmaceuticals for various therapeutic applications. Its role in creating new drug molecules is vital for advancing treatments and improving patient outcomes.
Used in Agrochemical Industry:
1,3-BIS(TRIMETHYLSILYL)BENZENE is also utilized in the agrochemical sector, where it serves as a precursor in the development of new agrochemicals. Its contribution to the synthesis of pesticides, herbicides, and other agricultural products helps enhance crop protection and yield.
Used in Specialty Chemicals Industry:
1,3-Bis(trimethylsilyl)benzene is used as a starting material in the production of specialty chemicals, which are tailored for specific applications in various industries such as coatings, adhesives, and materials science. Its versatility and reactivity make it an essential component in the creation of these high-value products.

InChI:InChI=1S/C12H22Si2/c1-13(2,3)11-9-7-8-10-12(11)14(4,5)6/h7-10H,1-6H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 541-73-1 1,3-Dichlorobenzene 
• 18090-43-2 3,6-bis(trimethylsilyl)cyclohexane-1,4-diene 
• 71-43-2 benzene 
• 15842-76-9 (2-chloro-phenyl)-trimethyl-silane 
• 4405-42-9 m-chlorophenyltrimethylsilane 

Downstream Products

• 55562-93-1 3-Trimethylsilyl-benzolsulfonsaeure-trimethylsilylester 
• 55499-82-6 C₁₂H₂₂O₆S₂Si₂ 
• 15290-24-1 3-nitro-1-(trimethylsilyl)benzene 
• 78627-92-6 1-nitro-2,4-bis(trimethylsilyl)benzene 
• 125973-47-9 1,3-dinitro-5-trimethylsilylbenzene 
• 107134-82-7 1,3-bis(dibromoboryl)benzene 
• 135129-91-8 3,5-bis(trimethylsilyl)trifluoroacetophenone 
• 768-32-1 trimethylphenylsilane 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 132236-18-1 2,2,2-Trifluoro-1-(3-trimethylsilylphenyl)-ethanone 
• 71-43-2 benzene 
• 172220-16-5 ((CH₃)5C₅)Rh(P(CH₃)3)(H)(C₆H₃(Si(CH₃)3)2) 
• 107134-71-4 [3-(dichloroboryl)phenyl]trimethylsilane 
• 591-18-4 1-Bromo-3-iodobenzene 

Relevant academic research and scientific papers

Theory and practice: Bulk synthesis of C3B and its H2- and Li-storage capacity

Previous theoretical studies of C3B have suggested that boron-doped graphite is a promising H2- and Li-storage material, with large maximum capacities. These characteristics could lead to exciting applications as a lightweight H

SELECTIVE MONO- OR DIMETALATION OF ARENES BY MEANS OF SUPERBASIC REAGENTS

If employed in tetrahydrofuran, stoichiometric amounts of butyllithium and potassium tert-butoxide react with benzene under clean monometalation.In hexane suspension, however, considerable amounts of meta- and para-disubstituted by-products are obtained (approx. 10percent).They become preponderant if a three-fold excess of the metalating agent is used.Naphthalene leads under the same conditions to a mixture of two mono- and ten di-substituted derivatives. - Alkyl groups, as present in tert-butylbenzene, retard the metalation at both m- and p-positions, while trialkylsilyl groups deactivate only m-position.In either case exclusive monosubstitution occurs. - Perdeuterobenzene undergoes metalation and subsequent electrophilic mono- or disubstitution to afford isotope labeled compounds with moderate, though synthetically attractive yields.The kinetic isotope effects and product ratios can be taken as evidence for aggregate formation at the level of both the superbasic metalating reagent and the organometallic intermediates.

Retinobenzoic Acids. 5. Retinoidal Activities of Compounds Having a Trimethylsilyl or Trimethylgermyl Group(s) in Human Promyelocytic Leukemia Cells HL-60

The retinoidal activities of trimethylsilyl or trimethylgermyl-containing retinobenzoic acids are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60.Compounds with a trimethylsilyl or trimethylgermyl gr

REVERSIBILITY IN THE HOMOLYTIC AROMATIC SUBSTITUTION WITH SILYL AND GERMYL RADICALS

The 3,6-bis(trimethylsilyl)cyclohexadienyl radical (1), generated from the corresponding cyclohexadiene, gave the expected p-bis(tri-methylsilyl)benzene (4) at 0 deg.C.At 130 deg.C, however, the reaction afforded trimethylsilylbenzene, 4, and m-bis(trimethylsilyl)benzene in 62, 17, and 5percent yield, respectively.The suggested elimination of the trimethylsilyl radical from the cyclohexadienyl radical is demonstrated by ESR.

ELECTRON SPIN RESONANCE AND CHEMICAL STUDIES ON THE 6-(TRIMETHYLSILYL)CYCLOHEXADIENYL AND RELATED RADICALS.

Various 3,6-disubstituted cyclohexadienyl radicals were generated and investigated by ESR at low temperature. Analysis of the ESR parameters indicated that the significant out-of-plane deformation of the carbon framework of 6-Me//3Si- and 6-Me//3Ge-substituted cyclohexadienyl radicals occurred to gain stabilization due to the effective hyperconjugation between the substituted methylene pseudo- pi orbital and the pi SOMO, while the 6-unsubstituted and 6-t-Bu cyclohexadienyl radicals were essentially planar. Investigation of the fate of the 3,6-bis(trimethylsilyl)cyclohexadienyl radical showed strong evidence for the temperature-dependent reversibility of the silyl radical addition to aromatics. The spontaneous elimination of the trimethylsilyl radical was proved by spin-trapping experiments.