20628-19-7

Usage

Uses

Used in Organic Synthesis:
N-(3-Methoxy-4-nitrophenyl)acetamide is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure allows for the formation of new bonds and reactions, contributing to the development of novel organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(3-Methoxy-4-nitrophenyl)acetamide serves as a key intermediate in the synthesis of drugs and pharmaceutical compounds. Its presence in these compounds can potentially enhance their therapeutic properties and effectiveness.
Used in Medicinal Chemistry:
N-(3-Methoxy-4-nitrophenyl)acetamide is utilized in medicinal chemistry for the design and development of new drugs. Its structural features and reactivity can be leveraged to create molecules with specific biological activities, targeting various diseases and medical conditions.
Used in Drug Development:
In the field of drug development, N-(3-Methoxy-4-nitrophenyl)acetamide plays a crucial role as a precursor in the synthesis of potential drug candidates. Its incorporation into these candidates can lead to the discovery of new therapeutic agents with improved pharmacological profiles.

Upstream product

• 588-16-9 m-methoxyacetanilide 
• 89102-03-4 3-acetoxy-4-nitroacetanilide 
• 6317-89-1 3-acetamidophenyl acetate 
• 591-27-5 m-Hydroxyaniline 
• 712-34-5 3-hydroxy-4-nitroacetanilide 
• 74-88-4 methyl iodide 
• 536-90-3 m-Anisidine 

Downstream Products

• 16292-88-9 3-methoxy-4-nitroanilin 
• 1351945-67-9 N,N'-[(E)-diazene-1,2-diylbis(3-methoxybenzene-4,1-diyl)]diacetamide 
• 93973-25-2 1-amino-2-methoxy-4-(N-acetylamino)benzene 
• 1356016-60-8 7-methoxy-quinolin-6-ylamine 
• 1356016-61-9 (E)-3-ethoxy-N-(3-methoxy-4-nitro-phenyl)-acrylamide 
• 54301-15-4 N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide hcrochloride 
• 92138-16-4 9-(4-Methanesulfonylamino-2-methoxy-phenylamino)-5-methyl-acridine-4-carboxylic acid methylamide; hydrochloride 
• 57165-06-7 N-(4-amino-3-methoxyphenyl)methanesulfonamide 
• 57165-05-6 3-methoxy-4-nitro-N-(methylsulfonyl)benzenamine 
• 103347-93-9 4-(3-methoxy-4-nitrophenyl)pyridine 
• 103348-14-7 2-Methoxy-4-pyridin-4-yl-phenylamine 
• 103347-95-1 2-Methoxy-4-pyridin-3-yl-phenylamine 
• 103347-94-0 2-Methoxy-4-pyridin-2-yl-phenylamine 
• 103347-92-8 3-[3-(methyloxy)-4-nitrophenyl]pyridine 

Relevant academic research and scientific papers

Vinylation of nitro-substituted indoles, quinolinones, and anilides with grignard reagents

The reaction of vinyl Grignard reagents with omethoxynitroarenes containing an electron-releasing substituent para to the nitro group proceeds through a pathway that is different from the initially expected Bartoli indole synthesis. Thus, instead of givin

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Azobenzene photoswitching without ultraviolet light

Most azobenzene-based photoswitches use UV light for photoisomerization. This can limit their application in biological systems, where UV light can trigger unwanted responses, including cellular apoptosis. We have found that substitution of all four ortho positions with methoxy groups in an amidoazobenzene derivative leads to a substantial (～35 nm) red shift of the n-π* band of the trans isomer, separating it from the cis n-π* transition. This red shift makes trans-to-cis photoswitching possible using green light (530-560 nm). The cis state is thermally stable with a half-life of ～2.4 days in the dark in aqueous solution. Reverse (cis-to-trans) photoswitching can be accomplished with blue light (460 nm), so bidirectional photoswitching between thermally stable isomers is possible without using UV light at all.

Syntheses and photophysical properties of fluorescent dibenzofurans, a dibenzothiophene, and carbazoles substituted with bensoxazole and hydroxyl groups to produce excited state intramolecular proton-transfer

Dibenzofurans, a dibenzothiophene, and carbazoles, each substituted with a 2-benzoxazolyl group as well as an ortho-hydroxyl group, were synthesized to produce fluors with fluorescence due to excited-state intramolecular proton-transfer. The orientations for Friedel-Crafts acylation of 3-methoxydibenzothiophene and of the analogous carbazole were determined. The fluors displayed absorption peaks in the 330-385 nm region with molar extinction coefficients up to 57,000. Fluorescence quantum efficiencies of 0.17-0.44 were obtained at wavelengths that had peak values from 540-600 nm. The fluors are of potential use as wavelength shifters in scintillating polystyrene fibers.

Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications

In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.