20632-12-6

Basic information

• Product Name: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one
• Synonyms: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one
• CAS NO: 20632-12-6
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21118
• Mol File: 20632-12-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 326.0±41.0 °C(Predicted)
• Appearance: /
• Density: 1.155±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one(20632-12-6)
• EPA Substance Registry System: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one(20632-12-6)

Safety Data

• Hazardous Substances Data: 20632-12-6(Hazardous Substances Data)

Usage

General Description

1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one, also commonly known as safrole, is a chemical compound with a molecular formula of C10H10O2. It is a colorless to pale yellow oily liquid that is commonly found in certain essential oils, such as sassafras and camphor. Safrole is known for its distinct aroma and is often used as a precursor in the synthesis of various fragrances, flavorings, and drugs. However, it is also a precursor in the synthesis of the illegal drug MDMA (ecstasy), and its use and distribution are regulated in many countries due to its potential for abuse and health risks. In addition, safrole has been identified as a potential carcinogen and is classified as a hazardous substance in some jurisdictions.

Upstream product

• 493-09-4 benzo-1,4-dioxane 
• 123-62-6 propionic acid anhydride 
• 79-03-8 propionyl chloride 

Downstream Products

• 1031396-51-6 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-ethyl-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)imidazolidine-2,4-dione 

Relevant articles and documents

AN EFFICIENT PROCESS FOR PREPARATION OF ACYL DERIVATIVES OF ALKYLENEDIOXYBENZENES

The present disclosure provides a process of preparation of compounds of Formula I comprising the step of : reacting an alkylenedioxybenzene compound of Formula II with an acyl halide of Formula III in presence of a solvent, wherein the step of reacting the alkylenedioxybenzene compound of Formula II with the acyl halide of Formula III is effected in presence of an amphoteric oxide and a Lewis acid so as to immediately quench the compound of formula H-X, formed during the course of the reaction, to substantially eliminate degradation of the compound of any of Formula I and II. The present disclosure also provides for process(es) for preparation of compound of Formula IVa, IVb and IVc.

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists

A novel series of 1,3-bistrifluoromethylcarbinol derivatives that act as liver X receptor (LXR) β-selective agonists was discovered. Structure-activity relationship studies led to the identification of molecule 62, which was more effective (Emax) and selective toward LXRβ than T0901317 and GW3965. Furthermore, 62 decreased LDL-C without elevating the plasma TG level and significantly suppressed the lipid-accumulation area in the aortic arch in a Bio F1B hamster fed a diet high in fat and cholesterol. We demonstrated that our LXRβ agonist would be potentially useful as a hypolipidemic and anti-atherosclerotic agent. In this manuscript, we report the design, synthesis and pharmacology of 1,3-bistrifluoromethylcarbinol derivatives.

CARBINOL DERIVATIVES HAVING CYCLIC LINKER

[Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.