20635-51-2

Upstream product

• 2216-92-4 N-phenylglycine ethyl ester 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 5326-87-4 N-(phenyl)bromoacetamide 
• 587-65-5 N-chloroacetyl-aniline 
• 420-04-2 CYANAMID 
• 103-01-5 N-Phenylglycine 
• 127-09-3 sodium acetate 
• 79-11-8 chloroacetic acid 
• 62-53-3 aniline 
• 10467-10-4 ethylmagnesium iodide 
• 60-29-7 diethyl ether 
• 6628-04-2 4-amino-2-methylquinoline 
• 105-53-3 diethyl malonate 

Downstream Products

• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 643-58-3 2-methylbiphenyl 
• 103-01-5 N-Phenylglycine 
• 64513-02-6 diphenyl-piperazinetetraone 
• 101081-61-2 5,6-dichloro-1,4-diphenyl-1,4-dihydro-pyrazine-2,3-dione 
• 6488-59-1 diphenylparabanic acid 

Relevant academic research and scientific papers

Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide - A potential antileishmanial agent

Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) i

A crystallographic and solid-state NMR study of 1,4-disubstituted 2,5-diketopiperazines

p-Disubstituted phenyldiketopiperazines 1 (R = H), 2 (R = NO2) and 3 (R = -N(CH3)2) were synthesized and characterized by NMR in solution and IR spectroscopy. The identity of the compounds was confirmed and their fragmenta

A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling

Several diketopiperazines have been shown to promote carbon-carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst. The structure of the diketopiperazine has an influence on its reductive potential and can help to promote the coupling of the more challenging aryl bromides with benzene.

The cytotoxic effects of diketopiperaizes against Leishmania donovani promastigotes and amastigotes

A series of diketopiperazine derivatives (1-12) were evaluated for their in vitro cytotoxic activity against Leishmania donovani promastigotes and amastigotes. Cytotoxicity study revealed that the number and types of the substituents in the phenyl rings h

Efficient synthesis of piperazinediones using potassium iodide catalysis in aqueous media

A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.

One-step diketopiperazine synthesis using phase transfer catalysis

A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%.

Synthesis of 1,4-diaryl-piperazine-2,5-diones: New behavior of N,N-dimethylformamide dimethyl acetal (DMFDMA)

Reactions of chloroacetamides (5) with N,N-dimethylformamide dimethyl acetal gave 1,4-diaryl-piperazine-2,5-diones 11a-e in good yield, rather than 1,5-diaryl-3,7-dimethoxy-1H,5H-[1,5]diazocine-2,6-diones (9a-e). Copyright Taylor & Francis Group, LLC.

Synthesis of symmetrically 1,4-disubstituted piperazine-2,5-diones: A new class of antileishmanial agents

A series of 1,4-diphenyl-2,5-dioxopiperazine derivatives were synthesised in one pot sequence. The compounds demonstrated appreciable cytotoxic activity against Leishmania donovani on both forms of the parasite, and the results suggested that some derivat

Electrochemical Studies on Haloamides. Part 4. Reactivity of Haloacetamides and Haloacetohydroxamates Toward Electrogenerated Diethyl Malonate Anion

The reactivity of haloacetamides and acetohydroxamates 1 and 2 toward electrogenerated diethyl malonate anion has been investigated.The course of the reaction primarily depends on the acidity of the amide NH group, which is mainly determined by the nature of the substituent, R, at the nitrogen atom.If this substituent is the same, the nature of the halogen atom also plays an important role.If the malonate anion can act as a base, products arising from follow-up reactions of the conjugated base of the substrate are formed and their structure is dependent on R.In particular, β-lactams arising from a formal insertion of a malonate residue into the amide skeleton are obtained from haloacetanilides.When the substrate cannot be deprotonated, the diethyl malonate anion behaves as a nucleophile provided that the leaving group is bromide.Chloro derivatives are rather stable toward malonate anion.

Electrochemical Studies on Haloamides. Part 3. Haloacetamides and Haloacetohydroxamates

The electrochemical reduction of haloacetamides and acetohydroxamates 1 and 2 at a mercury cathode in DMF-0.1 mol dm-3 TEAP (tetraethylammonium perchlorate) solutions has been investigated.The reduction leads to the corresponding dehalogenated products together with cyclic dimers, arising from follow-up reactions of the conjugated base of the starting compound.The same type of products, but in quite different yield, are formed when ethyl isobutyrate anion is electrogenerated in the presence of chloro derivatives 1.The reactivity of the substrates, and in particular the structure of the dimers, primarily depends on the nature of the substituent at the amide nitrogen.Possible reaction pathways leading to the products are suggested.