6488-59-1

Basic information

• Product Name: 1,3-diphenylimidazolidine-2,4,5-trione
• Synonyms: 1,3-Diphenyl-2,4,5-trioxoimidazolidine; 1,3-Diphenylimidazolidine-2,4,5-trione; 2,4,5-imidazolidinetrione, 1,3-diphenyl-; Imidazolidinetrione, diphenyl-
• CAS NO: 6488-59-1
• Molecular Formula: C₁₅H₁₀N₂O₃
• Molecular Weight: 266.2515
• Mol File: 6488-59-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 442.6°C at 760 mmHg
• Flash Point: 208.8°C
• Density: 1.41g/cm³
• Vapor Pressure: 4.95E-08mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: 1,3-diphenylimidazolidine-2,4,5-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diphenylimidazolidine-2,4,5-trione(6488-59-1)
• EPA Substance Registry System: 1,3-diphenylimidazolidine-2,4,5-trione(6488-59-1)

Safety Data

• Hazardous Substances Data: 6488-59-1(Hazardous Substances Data)

Usage

General Description

1,3-diphenylimidazolidine-2,4,5-trione, also known as DPT or diphenylhydantoin, is a chemical compound with the molecular formula C15H12N2O3. It is a derivative of hydantoin and is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. DPT has been studied for its potential anticonvulsant and antimicrobial properties. It has also been investigated for its potential use as a reagent in organic synthesis. As a solid, it appears as white to pale yellow crystals and is sparingly soluble in water. Due to its potential therapeutic properties, DPT continues to be an area of interest for researchers in the field of medicinal chemistry and drug development.

Upstream product

• 79-37-8 oxalyl dichloride 
• 603-54-3 N,N-diphenylurea 
• 21035-68-7 N,N'-bis(phenyl)-2-thioxoimidazolidine-4,5-dione 
• 103-71-9 phenyl isocyanate 
• 187964-68-7 N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride 
• 4755-77-5 Ethyl oxalyl chloride 
• 71-43-2 benzene 
• 56043-45-9 N,N,N',N'-tetramethylchlorformamidinium chloride 
• 102-07-8 bis(diphenyl)urea 
• 95-92-1 oxalic acid diethyl ester 
• 4514-33-4 (Z)-5-benzylidene-1,3-diphenylimidazolidin-2,4-dione 
• 617-37-8 oxalic acid monoethyl ester 
• 6784-22-1 phenylcarbamoyl cyanide 
• 128945-07-3 1,3-Diphenyl-2-ethoxycarbonylimino-4,5-bisimidazolidin 

Downstream Products

• 603-54-3 N,N-diphenylurea 
• 144-62-7 oxalic acid 
• 15719-64-9 methylammonium carbonate 
• 62-53-3 aniline 
• 1352131-40-8 5-(9-anthryl)-5-hydroxy-N,N'-diphenylimidazolidine-2,4-dione 
• 1352131-41-9 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione 
• 1267021-88-4 2-oxo-N-phenyl-2-(2,4,6-trimethylphenyl)acetamide 
• 3112-46-7 mesitylglyoxylic acid 
• 1352131-45-3 5-hydroxy-5-(2-naphthyl)-N,N'-diphenylimidazolidine-2,4-dione 
• 1352131-47-5 C₁₇H₁₆N₂O₃ 
• 29574-57-0 1,2-bis(2-naphthyl)ethan-1,2-dione 
• 1352131-39-5 5-hydroxy-N,N',5-triphenylimidazolidine-2,4-dione 
• 134-81-6 benzil 
• 1352131-46-4 C₃₁H₂₀N₂O₃ 

Relevant articles and documents

Urea Cyclisation Reaction Studies

Synthetic approaches of N-α-hydroxyalkyl amides or urea derivatives are described. In particularly, a new 1,4,6-oxadiazocine-2,5,8-trione was obtained by condensation of glyoxylic acid on urea derivatives in acidic catalysis condition.

Orthoamides and iminium salts LXXIV [1]. Reactions of N,N,N',N'- Tetramethyl-chloroformamidiniumChloride with metals

N,N,N',N'-Tetramethyl-formamidinium chloride (2a) reacts with elemental sodium in various solvents to give N,N,N',N',N'',N''-hexamethyl-guanidinium chloride (4a). The reaction of 2a with potassium affords N,N,N',N',N'',N'',N''', N'''-octamethyl-oxamidinium dichloride (3a). From the reaction of 2a with magnesium in different solvents in general result mixtures of the salts 4a, 3a and N,N,N',N'-tetramethyl-formamidinium chloride (10a). The composition of these mixtures depends on the solvent and the reaction temperature. Similar results are obtained, when a zinc'copper couple is used instead of magnesium. Very likely from 2a and magnesium or zinc, respectively, organometallic intermediates 11, 12 are formed which could be trapped by aromatic aldehydes and phenylisocyanate. The salt 2a can be reductively coupled by a low-valent titanium reagent to give the oxamidinium salt 3a.

Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione

Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol