20636-79-7

Upstream product

• 4281-46-3 2-hydroxypropyl-p-nitrophenyl phosphate 
• 67-56-1 methanol 
• 4281-48-5 2-hydroxypropyl phenyl phosphate 

Downstream Products

• 26964-04-5 2-methoxy-2-oxa-4-methyl-1,3,2-dioxaphospholane 
• 4281-46-3 2-hydroxypropyl-p-nitrophenyl phosphate 
• 10602-14-9 β-hydroxypropyl phosphate 

Relevant academic research and scientific papers

Hydrolysis of the RNA model substrate catalyzed by a binuclear ZrIV-substituted Keggin polyoxometalate

The reactivity and solution behaviour of the binuclear ZrIV-substituted Keggin polyoxometalate (Et2NH2)8[{α-PW11O39Zr(μ-OH)(H2O)}2]·7H2O (ZrK 2 : 2) towards

Upper rim guanidinocalix[4]arenes as artificial phosphodiesterases

Calix[4]arene derivatives, blocked in the cone conformation and functionalized with two to four guanidinium units at the upper rim were synthesized and investigated as catalysts in the cleavage of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosp

Detection of enzyme activity through catalytic signal amplification with functionalized gold nanoparticles

A cascade of two catalytic events was used to detect enzyme activity: When a peptide substrate acting as an inhibitor for a catalytic gold nanoparticle was hydrolyzed by an enzyme, the catalytic activity of the nanoparticle was restored, and a large amount of a yellow reporter molecule was produced (see picture; S=substrate, P=product). The assay can be made selective for a particular enzyme by changing the inhibitory peptide. (Chemical Equation Presented).

General base-guanidinium cooperation in bifunctional artificial phosphodiesterases

Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 ×10 4 in the most favorable case.

Efficient syntheses of artificial nucleases containing mono-, di- and tri-[12]aneN3 ligating units through click chemistry

Mono-, di-, and tri-nucleating [12]aneN3 ligands 3-5 have been efficiently prepared through the copper-mediated click reactions between propargyl modified [12]aneN3 2 and mono-, bis-, and tri-azido compounds. Their corresponding zinc

Origin of the dendritic effect in multivalent enzyme-like catalysts

Functionalization of multivalent structures such as dendrimers and monolayer passivated nanoparticles with catalytically active groups results in very potent catalysts, a phenomenon described as the positive dendritic effect. Here, we describe a series of

Hydrolytic cleavage of an RNA-model phosphodiester catalyzed by a highly negatively charged polyoxomolybdate [M07O24]6 Cluster

Hydrolysis of 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP), a commonly used RNA model substrate, was examined in molybdate solutions by means of 1H, 31P, and 95Mo NMR, Raman, and Mo K-edge extended X-ray absorption fine

A minimalist approach to understanding the efficiency of mononuclear Zn(ii) complexes as catalysts of cleavage of an RNA analog

Mononuclear complexes between Zn2+ and the following four macrocycles were prepared: 1,4,7,10-tetraazacyclododecane (1), 1-oxa-4,7,10-triazacyclododecane (2), 1,5,9-triazacyclododecane (3) and 1-hydroxyethyl-1,4,7-triazacyclononane (4). The pH

Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors

The synthesis of several cyclen based lanthanide [Eu(iii) and La(iii)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of

Determination of the activity of heterofunctionalized catalysts from mixtures

A conceptually new approach for the rapid determination of the activity of heterofunctionalized catalysts is described. A small library of catalysts is synthesized via a one-pot synthesis and screened for activity without separating the library members. The screening of libraries with varying catalyst distributions and subsequent deconvolution allows the determination of the activity of each catalyst separately. This approach is applied to a four-component library of biomimetic catalysts active in the cleavage of HPNP, a model compound for RNA. The rate constants for the four catalysts obtained via the deconvolution procedure are in very good agreement with the values obtained via the classical one catalyst-one screening approach. Simulations provide a hint of the scope and limitations of the approach. the Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2006.