206435-29-2

Upstream product

• 10242-36-1 2-(hydroxymethyl)pyridine 1-oxide 
• 206435-28-1 {[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid monophenyl ester 
• 206435-27-0 {[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid diphenyl ester 
• 206435-26-9 {[Allyloxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phosphonic acid diphenyl ester 
• 206435-23-6 [(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester 
• 4712-55-4 diphenyl hydrogen phosphite 

Relevant academic research and scientific papers

Optimization of the binding properties of PNA-(5')-DNA chimerae

The synthesis and evaluation of PNA-(5')-DNA chimerae containing either a 5'-amide (i.e. 1a), a 5'-phosphodiester (i.e. 1b) or 5'-phosphonate linkages (i.e. 1c,d) at the junction site are described. The 5'-linkages could be installed using either 5'-amino-5'-deoxythymidine phosphoramidite 2, O-[2-(2-aminoethyl)-(thymin-1-ylacetyl)amino]ethyl phosphoramidite 3, N-(2-aminoethyl)-N-(thymin-1-ylacetyl)aminomethyl phosphonate 4 or N-(2-aminoethyl)-N-(allyloxycarbonyl)aminomethyl phosphonate 5 as building blocks, respectively. It is shown that PNA-(5')-DNA of type 1a-c have a higher binding affinity with complementary RNA than native DNA, and that the antisense activity is mainly due to RNase H.