206446-45-9Relevant articles and documents
Synthetic method of antitumor heterocyclic drug intermediate 2-(3-azacyclobutyl) pyridine dihydrochloride
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Paragraph 0039; 0041, (2017/08/31)
The invention discloses a synthetic method of an antitumor heterocyclic drug intermediate 2-(3-azacyclobutyl) pyridine dihydrochloride. The synthetic method specifically comprises the following step of performing a two-step reaction to obtain a target compound 2-(3-azacyclobutyl) pyridine dihydrochloride by taking 3-iodine-1-t-butyloxycarboryl azetidine and 2-bromopyridine as raw materials. According to the synthetic method disclosed by the invention, the used raw materials are simple, low in cost and easily available, the reaction condition is simple, and the obtained product is high in chemical purity.
AMINO-HETEROCYCLIC COMPOUNDS
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Page/Page column 30, (2010/08/07)
The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.
Synthesis of C-substituted cyclic amines using azacycloalkyl organozinc reagents
Billotte
, p. 379 - 380 (2007/10/03)
Azetidine and piperidine derived organozinc species have been prepared from the corresponding azacycloalkyl iodides by direct Zn insertion. They have been shown to readily undergo Pd(0) mediated cross-coupling reactions and to transmetallate with CuCN.2LiCl.
