206447-91-8

Basic information

• Product Name: N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide
• Synonyms: N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide
• CAS NO: 206447-91-8
• Molecular Weight: 392.249
• Mol File: 206447-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide(206447-91-8)
• EPA Substance Registry System: N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide(206447-91-8)

Safety Data

• Hazardous Substances Data: 206447-91-8(Hazardous Substances Data)

Upstream product

• 506-96-7 Acetyl bromide 
• 206447-89-4 N-(p-methoxyphenyl) (2R,3S)-2,3-dihydroxy-3-phenylpropionamide 

Downstream Products

• 144790-01-2 (3R-cis)-3-acetyloxy-4-phenyl-2-azetidinone 
• 132127-34-5 (3R,4S)-3-hydroxy-4-phenylazetidin-2-one 
• 146924-90-5 (+)-cis-(3R,4S)-3-acetoxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 

Relevant articles and documents

A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one as a taxol side chain precursor

A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one, an important precursor for the paclitaxel side chain, has been developed using intramolecular cyclization of N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo- 3-phenylpropionamide which can be easily obtained by catalytic asymmetric dihydroxylation of N-(p-methoxyphenyl)-trans-cinnamide, followed by bromoacetylation.