146924-90-5Relevant articles and documents
Stereoselective synthesis of-lactams under diverse conditions: Unprecedented Observations
Das, Aparna,Bose, Ajay K.,Banik, Bimal Krishna
, p. 917 - 925 (2020/12/04)
ferent reaction conditions have been used for this study. It is important to note that the stereochemistry of the-lactam formation reaction depends on the conditions of the experiments, structures of the imines and acid chlorides, order of addition of the
Synthesis and biological evaluation of novel larotaxel analogues
Ren, Sumei,Wang, Yujie,Wang, Junfei,Gao, Dingding,Zhang, Minmin,Ding, Ning,Li, Yingxia
supporting information, p. 692 - 710 (2018/07/29)
Taxoids are a class of successful drugs and have been successfully used in chemotherapy for a variety of cancer types. However, despite the hope and promises that these taxoids have engendered, their utility is hampered by some clinic limitations. Extensive structure-activity relationship (SAR) studies of toxoids have been performed in many different laboratories. Whereas, SAR studies that based on the new-generation toxoid, larotaxel, have not been reported yet. In view of the advantages in preclinical and clinical data of larotaxel over former toxoids, new taxoids that strategicly modified at the C3’/C3′-N and C2 positions of larotaxel were designed, semi-synthesized, and examined for their potency and efficacy in vitro. As a result, it has been shown that the majority of these larotaxel analogues are exceptionally potent against both drug-sensitive tumor cells and tumor cells with drug resistance arising from P-glycoprotein over expression. Further in vivo antitumor efficacies investigations revealed A2 might be a potent antitumor drug candidate for further preclinical evaluation.
A mild and selective reduction of β-lactams: Rh-catalyzed hydrosilylation towards important pharmacological building blocks
Bornschein, Christoph,Lennox, Alastair J. J.,Werkmeister, Svenja,Junge, Kathrin,Beller, Matthias
supporting information, p. 1915 - 1919 (2015/03/18)
Four-membered N-heterocyclic compounds exhibit a broad range of pharmacological activities. Herein, we report a useful rhodium-catalyzed protocol for the activation of phenylsilane to reduce tertiary β-lactams. Reaction with the tertiary amides was select
