20662-95-7Relevant academic research and scientific papers
Synthesis of Extended Oxazoles III: Reactions of 2-(Phenylsulfonyl)methyl-4,5-diaryloxazoles
Patil, Pravin C.,Luzzio, Frederick A.
, p. 10521 - 10526 (2016/11/17)
2-((Phenylsulfonyl)methyl)-4,5-diphenyloxazole is a useful scaffold for synthetic elaboration at the 2-methylene position thereby affording extended oxazoles. The corresponding α-sulfonyl anion reacts smoothly with diverse alkyl halides giving monoalkylated (47-90%), dialkylated (50-97%), and cyclic (59-93%) products. The reductive desulfonylation of the monoalkylated and selected dialkylated products was optimized with a magnesium/mercuric chloride reagent system and afforded desulfonylated products in the range of 66-97%. The anti-inflammatory Oxaprozin was prepared using the α-sulfonyl carbanion strategy along with optimized desulfonylation.
Synthesis of 2-substituted 4,5-diphenyloxazoles under solvent-free microwave irradiation conditions
Lee, Jong Chan,Seo, Jang-Woo,Baek, Jong Wook
, p. 2159 - 2162 (2008/02/07)
A novel method for the direct conversion of deoxybenzoin into 2-alkyl-4,5-diphenyloxazoles and 2-aryl-4,5-diphenyloxazoles has been developed using treatment of HTIB and nitriles under solvent-free microwave irradiation conditions. Copyright Taylor & Fran
REACTION OF HYDROXYMETHYL ARYL KETONES WITH AROMATIC HYDROCARBONS
Bal'on, Ya. G.,Smirnov, V. A.
, p. 1712 - 1715 (2007/10/02)
The readily obtainable products from the condensation of arylglyoxals with carboxamides react with benzene and its analogs in the presence of concentrated sulfuric acid or phosphorus pentoxide in trifluoroacetic acid with the formation of arylmethyl aryl ketones, which are used for the synthesis of substituted azoles.
