74181-31-0

Upstream product

• 20662-95-7 4,5-diphenyl-2-propyloxazole 
• 123-72-8 butyraldehyde 
• 134-81-6 benzil 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 50889-04-8 (+/-)-2-oxo-1,2-diphenylethyl butyrate 

Relevant academic research and scientific papers

Polymer-supported zinc chloride: A highly active and reusable heterogeneous catalyst for one-pot synthesis of 2,4,5-trisubstituted imidazoles

A polymer-supported Lewis acid catalyst was prepared and found to be extremely efficient for the preparation of imidazole derivatives via three-component condensation of benzil, aldehydes, and ammonium acetate under mild conditions. The catalyst is stable

Catalytic conversion of 2,4,5-trisubstituted imidazole and 5-substituted 1H-tetrazole derivatives using a new series of half-sandwich (η6-p-cymene)Ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazone ligands

A new series of half-sandwich (η6-p-cymene) ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazide derivatives [Ru(η6-p-cymene)(Cl)(L)] [L = N'-(naphthalen-1-ylmethylene)thiophene-2-carbohydrazide (L1), N'-(anthracen-9-ylmethylene)thiophene-2-carbohydrazide (L2) and N'-(pyren-1-ylmethylene)thiophene-2-carbohydrazide (L3)] were synthesized. The ligand precursors and their Ru(II) complexes (1–3) were structurally characterized by spectral (IR, UV–Vis, NMR and mass spectrometry) and elemental analysis. The molecular structures of the ruthenium(II) complexes 1–3 were determined by single-crystal X-ray diffraction. All complexes were used as catalysts for the one-pot three-component syntheses of 2,4,5-trisubstitued imidazole and 5-substituted 1H-tetrazole derivatives. The catalytic studies optimized parameters as solvent, temperature and catalyst. The catalysts revealed very active for a broad range of aromatic aldehydes presenting either electron attractor or electron donor substituents and, although less active, moderate to high activities were observed for alkyl aldehydes.

Citrate trisulfonic acid: A heterogeneous organocatalyst for the synthesis of highly substituted Imidazoles

Citrate trisulfonic acid (CTSA), as a novel recyclable and eco-benign organocatalyst, was employed for the efficient and one-pot synthesis of trisubstituted imidazoles and tetrasubstituted imidazoles using aldehydes, ammonium acetate or aniline, and benzoin, benzyl, or 9,10-phenanthrenequinone under solvent-free conditions providing high to excellent yields. CTSA is easily prepared via the reaction of trisodium citrate and chlorosulfonic acid in high purity. Compared to the conventional procedures, the present method offers several advantages, including high yields, easy work-up, short reaction time, reusability of the catalyst, and simple purification of the products.

A 2, 4, 5 - tri-substituted imidazole of preparation method (by machine translation)

The invention relates to a 2, 4, 5 - tri-substituted imidazole of preparation method, the method is to be sequentially [...] or benzoins, aldehyde compounds, ammonium acetate and catalyst organic acid added in the reactor, in the 85 - 125 °C oil bath under the heating condition the reaction, after the reaction is complete to obtain a reaction mixture; the reaction mixture by washing, filtration, recrystallization after separation, to get the pure product 2, 4, 5 - tri-substituted imidazole. The present invention is simple, the production cost is low, and the yield is high, and has a good industrial application prospect. (by machine translation)

Synthesis and characterization of amino glucose-functionalized silica-coated NiFe2O4 nanoparticles: A heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of 2,4,5–trisubstituted imidazoles, benzo[d]imidazoles, benzo[d] oxazoles and azo-linked benzo[d]oxazoles

Amino glucose-functionalized silica-coated NiFe2O4 nanoparticles (NiFe2O4@SiO2@amino glucose) were chemically synthesized and characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), vibrating sample magnetometer (VSM), Zetasizer and Fourier transform infrared spectroscopy (FT-IR) instruments. NiFe2O4@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of 2,4,5-trisubstituted imidazoles through one-pot multicomponent condensation of benzil or benzoin, ammonium acetate with aryl aldehydes and for the synthesis of benzoxazoles using condensation reaction of 2-aminophenol with aryl aldehydes under solvent free condition. In the other study, this synthesized magnetically reusable catalyst was introduced as a new avenue for the synthesis of benzo[d]imidazoles using the reaction between aryl aldehydes and 1,2-diaminobenzene. These compounds were obtained in high yields and short reaction times. The catalyst could be easily recovered and reused for five cycles with almost consistent activity. Synthesized compounds were characterized by their physical constant, comparison with authentic samples, FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.

Shape-dependent catalytic activity of Fe3O4 nanostructures under the influence of an external magnetic field for multicomponent reactions in aqueous media

High-quality and high-active one-dimensional (1-D) Fe3O4 nanostructures were synthesized via an external magnetic field (EMF) at the intensity range 0-526 μT in aqueous solution, without using any surfactant and organic solvent at room temperature. Characterization of the products was carried out using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction spectroscopy (XRD), Fourier transform infrared spectrophotometry (FT-IR), a laser particle size analyzer, surface area (Brunauer-Emmett-Teller, BET), and vibrating sample magnetometer (VSM). The results show that EMF at a critical adjusted intensity has a great influence on the structural features such as the morphology, particle size, surface pore size distribution, and magnetic properties of the Fe3O4 nanostructure. The morphology changed from peg-like network structures to needle-like cage structures by an exposure synthesis treatment with EMF at an intensity of 362 μT. The catalytic activity of two nanostructures prepared in the presence and absence of EMF were compared in a tricomponents reaction (TCR) for the synthesis of trisubstituted imidazoles under electromagnetic irradiation. The best results were obtained for the catalyst produced in the presence of EMF while the tricomponent reaction was carried out in the absence of EMF. This EMF condition was used for the preparation of a series of alkyl-, aryl-, and heteroaryl-substituted imidazoles from the corresponding benzoin and benzil in aqueous solution as green reaction conditions. It was found that the catalyst can be efficiently recycled and reused for several repeating cycles without significant loss of catalytic activity.

Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

Highly efficient and eco-friendly synthesis of 2-alkyl and 2-aryl-4,5-diphenyl-1H-imidazoles under mild conditions

Highly efficient one-pot reactions of benzil or benzoin, ammonium acetate, and aliphatic or aromatic aldehydes were carried out in water in the presence of 1-methylimidazolium trifluoroacetate ([Hmim]TFA) under mild and green conditions. This approach can be useful for the three-component synthesis of 2-alkyl- and 2-aryl-4,5-diphenyl-1H-imidazoles in high yields. By conducting the reactions in aqueous media, the solid products were precipitated and could be isolated simply by filtration.

Synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in water using p-dodecylbenzenesulfonic acid as catalyst

2,4,5-Trisubstituted imidazoles have been synthesized by treatment of benzil with aldehydes and ammonium acetate in water under reflux in the presence of p-dodecylbenzenesulfonic acid as catalyst. The same reaction using an additional amine affords 1,2,4,

One-pot synthesis of polysubstituted imidazoles in a bronsted acidic deep eutectic solvent

A Bronsted acidic deep eutectic solvent based on choline chloride and p-toluenesulfonic acid was prepared and was found to be effective for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles with high yields. In addition, the deep eutectic solvent is non-toxic, cost-effective and recyclable.