206658-53-9Relevant academic research and scientific papers
Synthesis of N1-unsubstituted β-lactams via a facile deprotection of N1-[(α-thiophenyl)benzyl] group
Karupaiyan,Srirajan,Deshmukh,Bhawal
, p. 4375 - 4386 (1998)
A diastereoselective synthesis of (±) c/s-β-1actams (5 and 6) via cycloaddition reactions of N1-(α-thiophenyl)benzyl imines (3) with acid chlorides (4) in the presence of triethylamine is described. The deprotection of N1-(α-thiophenyl)benzyl group has been achieved by oxidation using potassium persulfate to give N-unsubstituted β-lactams (7) in good yields.
