2067-59-6

Basic information

• Product Name: N-{4-[bis(2-chloroethyl)amino]phenyl}benzamide
• CAS NO: 2067-59-6
• Molecular Formula: C₁₇H₁₈Cl₂N₂O
• Molecular Weight: 337.2436
• Mol File: 2067-59-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 420.8°C at 760 mmHg
• Flash Point: 208.3°C
• Density: 1.286g/cm³
• Vapor Pressure: 2.73E-07mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: N-{4-[bis(2-chloroethyl)amino]phenyl}benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[bis(2-chloroethyl)amino]phenyl}benzamide(2067-59-6)
• EPA Substance Registry System: N-{4-[bis(2-chloroethyl)amino]phenyl}benzamide(2067-59-6)

Safety Data

• Hazardous Substances Data: 2067-59-6(Hazardous Substances Data)

Upstream product

• 55743-71-0 bis(2-chloroethyl)(4-nitrophenyl)amine 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 100-00-5 4-chlorobenzonitrile 
• 2067-58-5 4-amino-N,N-bis(2-chloroethyl)aniline 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine and preparation method thereof

The invention particularly discloses a structural formula of a nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine, and a preparation method thereof. The preparation method comprises the following steps: preparing N,N-di(2-chloroethyl)-1,4-phenylenediamine; putting the N,N-di(2-chloroethyl)-1,4-phenylenediamine, dichloromethane and triethylamine into a reactor, cooling in ice-water bath, stirring, dropwise adding a mixed solution of benzoyl chloride and dichloromethane into the reactor, removing the ice-water bath after addition, conducting reaction at room temperature for 8 to 14 hours, sequentially performing washing, drying and normal-pressure distillation on the reaction liquid after the reaction is conducted completely, and purifying the distilled filter cake to obtain the product. The arylamine nitrogen mustard derivative provided by the invention can effectively reduce the toxic and side effects of nitrogen mustard on the premise of enhancing the treatment index of the nitrogen mustard, and has sterilization and inflammation-diminishing curative effects to reduce the risk of complication caused by the fact that the immunity is reduced after a patient is subjected to chemical therapy.