20688-29-3Relevant academic research and scientific papers
Bis-esters from maleic anhydrides under neutral conditions: Protection of the anhydride of the natural product cornexistin
Fields, Stephen C.,Dent III, William H.,Green III, F. Richard,Tromiczak, Eric G.
, p. 1967 - 1970 (1996)
Trimethylsilyldiazomethane converts maleic anhydride derivatives in alcoholic THF to bis-esters. The highly acid and base sensitive natural product cornexistin was converted to its bis-methyl ester in 70-75% yield and to the mixed benzyl/methyl ester in 61% yield. The mixed ester can be converted back to cornexistin via transfer hydrogenation.
A mild and selective dehydrohalogenating agent
Kendall, John T.,Lemal, David M.
, p. 171 - 174 (1997)
A discriminating reagent has been discovered which effects E2 elimination of HX from relatively reactive substrates. Readily prepared from lead(II) oxide and lithium bromide hydrate, this compound is a hydrated lithium dibromoplumbite.
REDUCTION D'α,α'-DIBROMOORTHOXYLENES PAR LES SELS CHROMEUX : GENERATION FACILE D'ORTHOQUINODIMETHANES.
Stephan, D.,Gorgues, A.,le Coq, A.
, p. 5649 - 5652 (1984)
α,α'-Dibromoorthoxylenes undergo a very fast reductive elimination on treatment with chromous chloride, affording the reactive intermediate orthoquinodimethanes which evolve into spiroorthoxlylenes 2 or may be trapped with dienophiles (adducts 3 and 4).Some attempts in the field of anthracycline precursors are reported.
Synthesis and activity studies of analogues of the rat selective toxicant norbormide
Rennison, David,Bova, Sergio,Cavalli, Maurizio,Ricchelli, Fernanda,Zulian, Alessandra,Hopkins, Brian,Brimble, Margaret A.
, p. 2963 - 2974 (2008/02/01)
Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. A series of NRB-related analogues were prepared to investigate the structural features responsible for, and the in vitro biological markers indicative of, in vivo lethality of the parent molecule in rats. Their synthesis and biological evaluation (vasoconstriction, vasodilation, mitochondrial dysfunction, cardiotoxicity and lethality) is described.
