2070-43-1Relevant academic research and scientific papers
1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors
Kuroyanagi, Jun-Ichi,Kanai, Kazuo,Sugimoto, Yuuichi,Horiuchi, Takao,Achiwa, Issei,Takeshita, Hiroshi,Kawakami, Katsuhiro
experimental part, p. 7593 - 7606 (2011/01/04)
Synthesis and in vitro antifungal evaluations of 1,3-benzoxazole-7- carbonitrile 3, 1,3-benzoxazole-4-carbonitrile 4, benzofuran 5, benzoxazine 7, and benzimidazole 8 were reported. Among them, 1,3-benzoxazole-4-carbonitrile was found to be a superior sca
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 96, (2009/06/27)
Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE
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Page/Page column 55-56, (2009/04/25)
Compounds of formula (I) and salts thereof are provided: formula (I) wherein R4, R5, R6, Q, A, and Y are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treatin
COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE
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Page/Page column 86; 130, (2009/04/25)
Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
BICYCLO HETEROCYCLIC COMPOUND HAVING ANTIFUNGAL ACTION
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Page/Page column 58, (2008/06/13)
It is intended to provide a 1,6-β-glucan synthase inhibitor which strongly inhibits proliferation and has a high safety. It is intended to provide a compound which can specifically or selectively expressing an antifungal action on a broad spectrum based on the action mechanism of inhibiting the synthesis of 1,6-β-glucan. Further, it is intended to provide a drug, in particular, an antifungal agent containing the above compound, its salt or a hydrate thereof. More specifically speaking, a compound represented by the following general formula (I), its salt or a hydrate thereof; and a drug or an antifungal agent containing the above compound, its salt or a hydrate thereof.
