2070-85-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-fluorobenzyl)ethane-1,2-diamine is used as a key intermediate in the synthesis of various pharmaceuticals for its unique reactivity and properties. It contributes to the development of new drugs with improved therapeutic effects and reduced side effects.
Used in Organic Chemistry:
N-(4-fluorobenzyl)ethane-1,2-diamine is used as a versatile building block in organic chemistry for the preparation of complex organic molecules. Its unique reactivity allows for the synthesis of a wide range of organic compounds with diverse applications.
Used in Materials Science:
N-(4-fluorobenzyl)ethane-1,2-diamine is used in the development of new materials with specific properties. Its incorporation into materials can enhance their performance, making them suitable for various applications in different industries.

InChI:InChI=1/C9H13FN2/c10-9-3-1-8(2-4-9)7-12-6-5-11/h1-4,12H,5-7,11H2

Upstream product

• 1648-04-0 di-(4-fluorobenzal)-ethylenediamine 
• 107-15-3 ethylenediamine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 519172-79-3 tert-butyl (2-((4-fluorobenzyl)amino)ethyl)carbamate 

Downstream Products

• 69840-65-9 1-(4-fluorobenzyl)-2-(nitromethylene)imidazolidine 
• 500782-66-1 (S)-1-(4-fluorobenzyl)-3-Isobutylpiperazin-2-one 
• 1349371-14-7 C₂₃H₂₆FN₅O₃ 
• 1348305-68-9 C₂₂H₂₄FN₅O₄ 

Relevant academic research and scientific papers

Design, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogues of IPPA08 by converting the pyridyl moiety of IPPA08 into phenyl groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound 25 at 0.75 mg/L lowered the LC50 value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC50 value was observed for IPPA08. The results of bee toxicity test showed that compound 25 display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a phenyl ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

Enantiomerically-enriched trichloromethyl-containing alcohols, obtained by asymmetric reduction, can be transformed regioselectively into 1-substituted piperazinones by modified Jocic reactions with little or no loss of stereochemical integrity. This meth