1648-04-0

Basic information

• Product Name: N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)
• Synonyms: N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)
• CAS NO: 1648-04-0
• Molecular Weight: 272.297
• Mol File: 1648-04-0.mol

Chemical Properties

• CAS DataBase Reference: N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)(1648-04-0)
• EPA Substance Registry System: N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)(1648-04-0)

Safety Data

• Hazardous Substances Data: 1648-04-0(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 107-15-3 ethylenediamine 

Downstream Products

• 2070-85-1 N¹-4-fluorobenzylethane-1,3-diamine 
• 1227469-22-8 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole 
• 1344673-99-9 7,10-bis(4-fluorobenzyl)-2,2,4,4-tetrachloro-1,3,5,7,10-pentaaza-2λ5,4λ5,6λ5-triphosphaspiro[4.5]deca-1,3,5-triene 
• 1344674-10-7 7,10-bis(4-fluorobenzyl)-2,2,4,4-tetrapyrrolidin-1-yl-1,3,5,7,10-pentaaza-2λ5,4λ5,6λ5-triphosphaspiro[4.5]deca-1,3,5-triene 
• 1344674-11-8 7,10-bis(4-fluorobenzyl)-2,2,4,4-tetramorpholin-4-yl-1,3,5,7,10-pentaaza-2λ5,4λ5,6λ5-triphosphaspiro[4.5]deca-1,3,5-triene 
• 1344674-12-9 7,10-bis(4-fluorobenzyl)-2,2,4,4-tetra-1,4-dioxa-8-azaspiro[4.5]dec-8-yl-1,3,5,7,10-pentaaza-2λ5,4λ5,6λ5-triphosphaspiro[4.5]deca-1,3,5-triene 
• 1581-26-6 N¹,N²-bis(4-fluorobenzyl)ethane-1,2-diamine 
• 906439-64-3 C₂₀H₁₈F₂N₂O₂S₂ 

Relevant articles and documents

Synthesis, crystal structure and photo-induced isomerization of [N,N′-bis(4-fluorobenzylidene)ethylenediamine]bromo(triphenyl-phosphine) copper(I)

The title Schiff base complex is a model compound for photoisomerization reactions which occur in photobiological processes such as vision. The Schiff base ligand and the complex have been prepared in a one-pot synthesis. In the crystal structure of the complex, copper has a distorted tetrahedral coordination. Photochemical investigations in solution reveal time-resolved spectroscopic changes that are interpreted in terms of a transformation from E to Z configuration of the C=N bonds of the coordinated Schiff base ligand. Application of multivariate curve resolution and non-linear least squares curve fitting to the spectroscopic profiles provides a rate constant of 0.11 min 1 for the photoisomerization and a quantum yield of 0.246.

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy

Design and application of diimine-based copper(i) complexes in photoredox catalysis

Structurally different bis(imino)copper(i) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in the ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.

Synthesis and biological evaluation of novel substituted-imidazolidine derivatives

A series of newer substituted-imidazolidine derivatives 3a-k were synthesized and assayed in vivo to investigate their anti-inflammatory, analgesic and antiulcer activity. The results of biological evaluation revealed that the three compounds, 4-[1,3-bis(4-hydroxy-3-methoxybenzyl)-2- imidazolidinyl]phenyldiethylamine (3g), 4-[1,3-bis(3-Ethoxy-4-hydroxybenzyl)-2- imidazolidinyl] phenyldiethylamine (3h) and 4-(1,3-bis(benzo[d][1,3]dioxol-5- ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethylbenzenamine (3j) were good in their anti-inflammatory and analgesic actions. Additionally these derivatives showed superior GI safety profile as compared to that of the standard drug in terms of low severity index. The results are statistically treated for its significance.

Zn2+-K10-clay (clayzic) as an efficient water-tolerant, solid acid catalyst for the synthesis of benzimidazoles and quinoxalines at room temperature

A very simple, green and efficient protocol is developed in which zinc chloride-exchanged K10-montmorillonite (clayzic) is employed as a Lewis acid catalyst in aqueous media at room temperature for the synthesis of various benzimidazoles and quinoxalines from carbonyl compounds and o-phenylenediamine. Among the various catalysts (including claycop and Zn2+-Y) studied, clayzic produces benzimidazoles and quinoxalines in higher yield, and with a flexible diamine such as ethylenediamine only the bis-Schiff base is formed. Other salient features of this protocol include milder conditions, atom-economy, absence of coupling agents, and no wastes.

Phosphorus-nitrogen compounds part 22. Syntheses, structural investigations, biological activities and DNA interactions of new mono and bis (4-fluorobenzyl) spirocyclophosphazenes

The reactions of hexachlorocyclotriphosphazene, N3P 3Cl6, with mono (1 and 2) and bis(4-fluorobenzyl) diamines (3-5), FPhCH2NH(CH2)nNHR (RH or FPhCH 2-), produce mono (1a and 2a)

A zeolite promoted expeditious one-pot synthesis of 1-arylmethyl-4,5- dihydro-2-aryl-1H-imidazole

(Chemical Equation Presented) A series of 1-arylmethyl-4,5-dihydro-2-aryl- 1H-imidazoles were synthesized expeditiously in good yields from 1,2-diaminoethane and aromatic aldehydes in the presence of zeolite under microwave irradiation in the absence of s