207122-91-6Relevant academic research and scientific papers
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone
Edwards, James P.,West, Sarah J.,Pooley, Charlotte L. F.,Marschke, Keith B.,Farmer, Luc J.,Jones, Todd K.
, p. 745 - 750 (1998)
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
