Bioorganic and Medicinal Chemistry Letters p. 745 - 750 (1998)
Update date:2022-07-30
Topics:
Edwards, James P.
West, Sarah J.
Pooley, Charlotte L. F.
Marschke, Keith B.
Farmer, Luc J.
Jones, Todd K.
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
View MoreShanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
Daqing E-shine Chemical Co.,LTD
Contact:0086-024-31285112
Address:Hongweiyuan area, Ranghulu district
website:http://www.hope-chem.com
Contact:86-21-58090396-805
Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
website:https://www.bocsci.com/
Contact:1-631-485-4226
Address:Ramsey Road
Doi:10.1016/S0040-4020(98)00235-X
(1998)Doi:10.1016/j.tetlet.2007.01.104
(2007)Doi:10.1016/j.tet.2006.06.016
(2006)Doi:10.1246/bcsj.41.1423
(1968)Doi:10.3758/BF03195775
(1950)Doi:10.1246/bcsj.41.1711
(1968)
