Bioorganic and Medicinal Chemistry Letters p. 745 - 750 (1998)
Update date:2022-07-30
Topics:
Edwards, James P.
West, Sarah J.
Pooley, Charlotte L. F.
Marschke, Keith B.
Farmer, Luc J.
Jones, Todd K.
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
View MoreZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.
website:http://www.zenvasino.com
Contact:+86-138-72658998
Address:Shibeishan Road,Zhijiang, Hubei, China
zhuzhou zhongle chemical co. ltd.
Contact:+86-0731 28228409
Address:Zhuzhou, Hunan, China
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)
Contact:+86-571-87046953
Address:No. 37, Qingchun Road
Shanghai Pinewood Fine Chemical Co., Ltd.
website:http://www.pinewoodchem.com
Contact:0086-21-62417129，62414096
Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
PharmaResources(Kaiyuan)CO,.Ltd
Contact:+86-21-50720028
Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Doi:10.1016/S0040-4020(98)00235-X
(1998)Doi:10.1016/j.tetlet.2007.01.104
(2007)Doi:10.1016/j.tet.2006.06.016
(2006)Doi:10.1246/bcsj.41.1423
(1968)Doi:10.3758/BF03195775
(1950)Doi:10.1246/bcsj.41.1711
(1968)
