Bioorganic and Medicinal Chemistry Letters p. 745 - 750 (1998)
Update date:2022-07-30
Topics:
Edwards, James P.
West, Sarah J.
Pooley, Charlotte L. F.
Marschke, Keith B.
Farmer, Luc J.
Jones, Todd K.
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
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Doi:10.1016/S0040-4020(98)00235-X
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