20720-46-1

Upstream product

• 55951-93-4 1,2:5,6-di-O-isopropylidene-3-O-triflyl-α-D-glucofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 4613-62-1 3-deoxy-1,2;5,6-di-O-isopropylidene-α-D-glucofuranoside 
• 4005-46-3 3-deoxy-1,2-O-isopropylidene-D-glucose 
• 98-88-4 benzoyl chloride 

Downstream Products

• 20720-47-2 6-O-benzoyl-3-deoxy-1,2-O-isopropylidene-5-O-tosyl-α-D-ribo-hexofuranose 
• 158226-43-8 6-O-benzoyl-3,5-dideoxy-5-iodo-1,2-O-isopropylidene-β-L-lyxo-hexofuranose 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS

The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis

Homologues of anti-HIV active isodideoxynucleosides

The synthesis of a homologous series of compounds related to the anti-HIV active class of compounds known as (S,S)-isodideoxynucleosides has been completed by a convergent route using a modified carbohydrate intermediate. This precursor, synthesized from D-glucose, was coupled with a variety of natural purine and pyrimidine bases to regiospecifically afford the desired new class of compounds.

Chiral Building Units from Carbohydrates, VI. - Synthesis of (2R,5RS)- and (2S,5RS)-2-Ethyl-1,6-dioxaspirononane (Chalcogran) from D-Glucose

Starting from D-glucose the syntheses of the title compounds (15 and 25) are described.Key compounds are the tetradeoxytrimethylenedithioacetals 11 and 23 which lead by the Corey-Seebach reaction with the THP-blocked 3-bromo-1-propanol to the fully blocked, open-chained products 13 and to the (S)-analogous compound.Mild cleavage of the dithiane group and the THP-protective groups yields after spontaneous cyclisation 15 and 25.The open-chained mono-ol 11 with D-configurated hydroxyl group can be converted into the L-configurated product 22 by esterification with benzoic acid/ triphenylphosphane/ diethyl azodicarboxylate.