207231-22-9

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1638101-74-2 2,2,2-trifluoro-N-(2-hydroxy-4-(trifluoromethoxy)phenyl)acetamide 
• 207231-08-1 2-(4-Hydroxy-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207231-06-9 2-(4-Amino-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207231-23-0 ethyl 4-chloro-6-(trifluoromethoxy)quinoline-3-carboxylate 
• 175203-85-7 ethyl 4-hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylate 

Relevant academic research and scientific papers

High affinity central benzodiazepine receptor ligands: Synthesis and structure-activity relationship studies of a new series of pyrazolo[4,3- c]quinolin-3-ones

A large series of 2-aryl(heteroaryl)-2,5-dihydropyrazolo[4,3-c]quinolin- 3-(3H)-ones, carrying appropriate substituents at the quinoline and N2- phenyl rings, were prepared and tested as central benzodiazepine receptor ligands. Results from structure-affinity relationship studies were in full agreement with previously proposed pharmacophore models and, in addition, quantitative structure-activity analysis gave further significant insight into the main molecular determinants of high benzodiazepine receptor affinity. The intrinsic activity of some active ligands was also determined and preliminary discussed.

Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones

The synthesis of new nucleoside derivatives from 6- and 7-trifluoromethoxy-4-quinolones is described. The present synthesis is a combination of the Gould-Jacobs reaction for the preparation of 4-quinolones and a modified Vorbrüggen reaction for the construction of nucleoside derivatives. The target compounds were tested against murine gammaherpesvirus MHV-68 type.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.