207231-23-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-(trifluoromethoxy)quinoline-3-carboxylic acid ethyl ester is used as a building block for the synthesis of pharmaceuticals. Its unique structure and functional groups make it suitable for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-Chloro-6-(trifluoromethoxy)quinoline-3-carboxylic acid ethyl ester is also used as a building block for the synthesis of agrochemicals. Its versatile chemical properties allow for the creation of compounds with potential applications in agriculture, such as pesticides or herbicides.

InChI:InChI=1/C13H9ClF3NO3/c1-2-20-12(19)9-6-18-10-4-3-7(21-13(15,16)17)5-8(10)11(9)14/h3-6H,2H2,1H3

Upstream product

• 207231-22-9 diethyl 2-[(4-(trifluoromethoxy)phenylamino)methylidene]malonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 461-82-5 4-(trifluoromethoxy)aniline 
• 175203-85-7 ethyl 4-hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylate 

Downstream Products

• 207231-05-8 2-(4-Nitro-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207231-08-1 2-(4-Hydroxy-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207231-06-9 2-(4-Amino-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207230-99-7 2-(3-Nitro-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 207231-07-0 2-(4-Methoxy-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 
• 340811-91-8 8-trifluoromethoxy-2-(4-hydroxy-3-nitrophenyl)pyrazolo[4,3-c]quinolin-3(5H)-one 

Relevant academic research and scientific papers

PAPD5 INHIBITORS AND METHODS OF USE THEREOF

The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, and aging-related and other degenerative disorders.

High affinity central benzodiazepine receptor ligands: Synthesis and structure-activity relationship studies of a new series of pyrazolo[4,3- c]quinolin-3-ones

A large series of 2-aryl(heteroaryl)-2,5-dihydropyrazolo[4,3-c]quinolin- 3-(3H)-ones, carrying appropriate substituents at the quinoline and N2- phenyl rings, were prepared and tested as central benzodiazepine receptor ligands. Results from structure-affinity relationship studies were in full agreement with previously proposed pharmacophore models and, in addition, quantitative structure-activity analysis gave further significant insight into the main molecular determinants of high benzodiazepine receptor affinity. The intrinsic activity of some active ligands was also determined and preliminary discussed.