207231-06-9

Upstream product

• 100-16-3 4-nitrophenylhydrazone 
• 207231-22-9 diethyl 2-[(4-(trifluoromethoxy)phenylamino)methylidene]malonate 
• 175203-85-7 ethyl 4-hydroxy-6-(trifluoromethoxy)quinoline-3-carboxylate 
• 207231-23-0 ethyl 4-chloro-6-(trifluoromethoxy)quinoline-3-carboxylate 
• 461-82-5 4-(trifluoromethoxy)aniline 
• 207231-05-8 2-(4-Nitro-phenyl)-8-trifluoromethoxy-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one 

Relevant academic research and scientific papers

High affinity central benzodiazepine receptor ligands: Synthesis and structure-activity relationship studies of a new series of pyrazolo[4,3- c]quinolin-3-ones

A large series of 2-aryl(heteroaryl)-2,5-dihydropyrazolo[4,3-c]quinolin- 3-(3H)-ones, carrying appropriate substituents at the quinoline and N2- phenyl rings, were prepared and tested as central benzodiazepine receptor ligands. Results from structure-affinity relationship studies were in full agreement with previously proposed pharmacophore models and, in addition, quantitative structure-activity analysis gave further significant insight into the main molecular determinants of high benzodiazepine receptor affinity. The intrinsic activity of some active ligands was also determined and preliminary discussed.