20733-21-5Relevant academic research and scientific papers
Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones
Feng, Yueji,Tuo, Yanyan,Zhang, Xiaohui,Zheng, Qing-Zhong
supporting information, p. 768 - 772 (2022/02/03)
A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is
An efficient and novel method for the synthesis of aromatic sulfones under solvent - Free conditions
Hajipour,Mallakpour,Imanzadch
, p. 237 - 239 (2007/10/03)
A manipulative simple and rapid reaction of arensulfonyl chloride with aromatic hydrocarbons is described. The reaction is conducted under Friedel-Crafts conditions in the absences of solvent using aluminium chloride as catalysts.
Orientation in benzenesulphonylation of haloroluenes and haloanisoles - A study by NMR spectra
Gurumani, V.,Swaminathan, M.,Mangalamudaiyar, A.
, p. 281 - 287 (2007/10/02)
Halotoluenes and haloanisoles (F, Cl and Br) have been sulphonylated using benzenesulphonyl chloride and anhyd.AlCl3, and the products recovered and analysed by proton and carbon-13 NMR spectra.Formation of a minor product is found in most of the halotoluenes and in m-haloanisoles.Halogens predominantly orient the substitution in halotoluenes and methoxy group in haloanisoles.Fluorine behaves differently from other halogens in p-fluorotoluene and m-fluoroanisole.This anomaly has been discussed.Proton and carbon-13 NMR spectral data for some diphenyl sulphones obtained in benzenesulphonylation reaction have been reported.
