207397-53-3

Upstream product

• 2227-79-4 benzenecarbothioamide 
• 173316-57-9 N'-[1-(4-oxo-2-phenyl-4H-thiazol-5-ylidene)-ethyl]-hydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 220449-52-5 2-phenyl-5-acetyl-4-thiazolyl triflate 
• 839731-35-0 2-bromo-1-(4-hydroxy-2-phenyl-thiazol-5-yl)-ethanone 
• 220449-62-7 1-(2-phenyl-4-phenylethynyl-thiazol-5-yl)-ethanone 
• 10045-50-8 1-(2-phenylthiazol-5-yl)ethan-1-one 
• 4636-45-7 2,2'-diphenyl-[4,5']bithiazolyl-4'-one 

Relevant academic research and scientific papers

Efficient synthesis of novel polyfunctionalised 4,5′-bithiazol- 4′-ol derivatives

2-Thiazolin-4-one derivatives, obtained by reaction of tert-butyl (3-methoxy-1-methyl-3-oxoprop-1-enyl)diazenecarboxylate with aryl thioamides, were transformed into 5-bromoacetyl-4-hydroxythiazole derivatives by polymer-supported reagents and simple work-up procedures. The compounds thus synthesised were coupled with thioamides bearing valuable functional groups affording novel polyfunctionalised 4,5′-bithiazol-4′-ol derivatives.

2-Substituted 5-Acetyl-4-Hydroxythiazoles

5-acetyl-4-hydroxythiazoles bearing various substituents at position 2 of the thiazole ring have been obtained from the parent NH-BOC protected hydrazino-hydrazono derivatives of 2-thiazolin-4-ones by hydrogen chloride-promoted cleavage of the NH-BOC prot