207398-35-4

Upstream product

• 192385-50-5 4-pivaloyloxy-2-butynal 
• 207398-34-3 2-((E)-3,7-Dimethyl-octa-2,6-dienyl)-3-oxo-pentanedioic acid dimethyl ester 
• 5389-87-7 1-chloro-3,7-dimethylocta-2,6-diene 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 

Downstream Products

• 207402-10-6 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester 
• 207398-36-5 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester 
• 60435-90-7 5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide 
• 38877-93-9 7-O-Methylmycophenolic acid 
• 24280-93-1 mycophenolic acid 
• 31858-66-9 methyl mycophenolate 
• 207402-09-3 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of mycophenolic acid

A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1.

A total synthesis of mycophenolic acid

A total convergent synthesis of mycophenolic acid 1 from 2-geranyl- dimethyl-1,3-acetonedicarboxylate 2 and 4-pivaloyloxy-2-butynal using a Michael addition-Dieckmann cyclization as key step is described.