60435-90-7

Usage

Uses

Used in Pharmaceutical Industry:
6-O-Methyl Mycophenolic Acid Methyl Ester is used as an impurity in the production of Mycophenolic Acid (M831500), which is an antibiotic. Mycophenolic Acid functions as a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme that plays a role in the de novo synthesis of purine nucleotides.
Used in Environmental Contaminant Analysis:
6-O-Methyl Mycophenolic Acid Methyl Ester is utilized in the identification and analysis of environmental contaminants. Its presence can indicate potential contamination in various environmental samples, which is crucial for monitoring and maintaining environmental safety.
Used in Food Contaminant Analysis:
In the food industry, 6-O-Methyl Mycophenolic Acid Methyl Ester is used for detecting food contaminants. Its identification in the food supply can signal the presence of unwanted substances, which is essential for ensuring food safety and quality.

Upstream product

• 186581-53-3 diazomethane 
• 38877-93-9 7-O-Methylmycophenolic acid 
• 24280-93-1 mycophenolic acid 
• 616-38-6 carbonic acid dimethyl ester 
• 31858-66-9 methyl mycophenolate 
• 74-88-4 methyl iodide 
• 207398-35-4 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dihydroxy-benzoic acid methyl ester 
• 545392-50-5 6-[5-(3,3-dimethyl-oxiranyl)-3-methyl-pent-2-enyl]-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one 
• 207402-10-6 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester 
• 207402-09-3 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester 
• 207398-36-5 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester 
• 207398-37-6 6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one 
• 545392-47-0 (E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal 

Downstream Products

• 38877-93-9 7-O-Methylmycophenolic acid 
• 24280-93-1 mycophenolic acid 
• 78968-68-0 (E)-6-(3,4-Bis-hydroxymethyl-2,6-dimethoxy-5-methyl-phenyl)-4-methyl-hex-4-en-1-ol 
• 31858-66-9 methyl mycophenolate 

Relevant academic research and scientific papers

Mycophenolic acid as a latent agonist of PPARγ

Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we u

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment

Mycophenolic acid (MPA), an inhibitor of IMP-dehydrogenase (IMPDH), is used worldwide in transplantation. Recently, numerous studies showed its importance in cancer treatment. Consequently, MPA entered clinical trials in advanced multiple myeloma patients

Total synthesis of mycophenolic acid

A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1.

A total synthesis of mycophenolic acid

A total convergent synthesis of mycophenolic acid 1 from 2-geranyl- dimethyl-1,3-acetonedicarboxylate 2 and 4-pivaloyloxy-2-butynal using a Michael addition-Dieckmann cyclization as key step is described.

Convenient O-methylation of phenols with dimethyl carbonate

Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.