207611-58-3

Basic information

• Product Name: 2-BROMO-1,1-BINAPHTHYL
• Synonyms: 2-BROMO-1,1-BINAPHTHYL;2-Bromo-1,1'-binaphthalene
• CAS NO: 207611-58-3
• Molecular Formula: C₂₀H₁₃Br
• Molecular Weight: 333.22
• Mol File: 207611-58-3.mol

Chemical Properties

• Boiling Point: 435.2±14.0 °C(Predicted)
• Appearance: white/Powder
• Density: 1.393±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-BROMO-1,1-BINAPHTHYL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1,1-BINAPHTHYL(207611-58-3)
• EPA Substance Registry System: 2-BROMO-1,1-BINAPHTHYL(207611-58-3)

Safety Data

• Hazardous Substances Data: 207611-58-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-1,1-BINAPHTHYL is used as a chiral ligand for the synthesis of enantiomerically pure pharmaceutical compounds. Its ability to facilitate stereochemically controlled reactions is essential for the production of drugs with specific therapeutic effects and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-1,1-BINAPHTHYL serves as a chiral ligand in the synthesis of enantiomerically pure agrochemicals. This ensures that the active ingredients have the desired biological activity against pests or diseases while minimizing potential environmental impacts.
Used in Advanced Materials Industry:
2-BROMO-1,1-BINAPHTHYL is utilized as a chiral building block in the development of advanced materials with specific properties. Its role in enabling the synthesis of enantiomerically pure compounds contributes to the creation of materials with tailored characteristics for various high-tech applications.
Used in Organic Synthesis:
As a key intermediate in organic synthesis, 2-BROMO-1,1-BINAPHTHYL is employed in the preparation of various chiral compounds. Its reactivity and utility in facilitating asymmetric reactions make it an important tool for chemists to construct complex molecular architectures with precise stereochemistry.

Upstream product

• 74866-28-7 2,2'-dibromo-1,1'-binaphthyl 

Downstream Products

• 318250-04-3 2-[bis-(3,5-bis-trifluoromethyl-phenyl)-phosphinoyl]-[1,1']binaphthalenyl 
• 194-58-1 7H-Dibenzofluorene 
• 92-52-4 biphenyl 
• 604-53-5 1,1'-bisnaphthalene 
• 1602492-96-5 2'-(diphenylphosphoryl)-1,1'-binaphthyl-2-yl acetate 
• 132532-07-1 [1,1'-binaphthalen]-2-yldiphenylphosphine oxide 
• 264188-44-5 (S)-2-diphenylphosphino-1,1'-binaphthyl 

Relevant articles and documents

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

A microflow system consisting of micromixers and microtube reactors provides an effective method for the introduction of two electrophiles onto dibromobiaryls. Selective monolithiation of dibromobiaryls, such as 2,2'-dibromobiphenyl, 4,4'-dibromobiphenyl, 2,7-dibromo-9,9-dioctylfluorene, 2,2'-dibromo-1,1'-binaphthyl, and 2,2'-dibromobibenzyl with 1 equiv of n-butyllithium followed by the reaction with electrophiles was achieved using a microflow system by virtue of fast micromixing and precise temperature control. Sequential introduction of two different electrophiles was achieved using an integrated microflow system composed of four micromixers and four microtube reactors to obtain unsymmetrically substituted biaryl compounds.

Selective monolithiation of dibromobiaryls using microflow systems

(Chemical Equation Presented) Selective monolithiation of dibromobiaryls, such as 2,2′-dibromobiphenyl, 4,4′-dibromobiphenyl, 2,7-dibromo-9,9-dioctylfluorene, 2,2′-dibromo-1,1′-binaphthyl, and 5,5′-dibromo-2,2′-bithiophene, with 1 equiv of n-butyllithium followed by the reaction with electrophiles was achieved using a microflow system by virtue of fast micromixing and precise temperature control. Sequential introduction of two different electrophiles based on this method was also achieved using a microflow system composed of four micromixers and four microtube reactors.