2078-22-0Relevant articles and documents
Bis-ortho-metalation/silylation of unprotected o-phthalic acids. Straightforward access to new silylated N-hydroxyphthalimide (NHPI) analogs
Michaux, Jér?me,Bessires, Bernard,Einhorn, Jacques
, p. 48 - 50 (2012)
The one pot, in situ ortho-metalation/silylation of unprotected o-phthalic acids using lithium tetramethylpiperidide (LiTMP) and chlorotrimethylsilane is described. This method gives a straightforward access to silylated phthalic anhydrides. These can be
Synthesis of trimethylsilyl carboxylates by HMDS under solvent-free conditions
Jereb, Marjan,Lakner, Janja
, p. 5713 - 5723 (2016/08/23)
A broad set of structurally different carboxylic acids were transformed into their trimethylsilyl esters with HMDS in a practically completely solvent-free process, while a catalytic amount of iodine was required in some cases. The process has several advantages over the known methods: untreated reactants, air atmosphere, mild and neutral conditions, no evolution of hydrogen halide, no need of an additional base, low amount of waste, completely without chromatography, low consumption of energy, and operational simplicity.