207971-22-0Relevant academic research and scientific papers
Design and synthesis of biotin-tagged photoaffinity probes of jasmonates
Gu, Min,Yan, Jianbin,Bai, Zhiyan,Chen, Yue-Ting,Lu, Wei,Tang, Jie,Duan, Liusheng,Xie, Daoxin,Nan, Fa-Jun
scheme or table, p. 3012 - 3019 (2010/07/08)
Jasmonates (JAs) are a class of oxylipin compounds that play diverse roles in plant defense and development. The F-box protein coronatine insensitive1 (COI1) plays a crucial role in the JA signaling pathway. To determine whether COI1 binds directly to jasmonates, three biotin-tagged photoaffinity probes for JAs, a jasmonic acid photoaffinity probe (PAJA), a JAIle photoaffinity probe (PAJAIle), and a coronatine photoaffinity probe (PACOR), were designed and synthesized based on analysis of JA structure-activity relationships and molecular modeling of the interaction between COI1 and JAs. Among them, PACOR exhibited the most significant biological activity in inhibiting root growth, promoting accumulation of JA-responsive proteins, and triggering COI1-JAZ1 interaction in Arabidopsis seedlings. PACOR is an effective tool for elucidating the interaction between COI1 and JA.
Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling
Hashimoto, Makoto,Hatanaka, Yasumaru,Yang, Jing,Dhesi, Jaswant,Holman, Geoffrey D.
, p. 119 - 127 (2007/10/03)
New diazirine based bis-glucose derivatives for tagging glucose transporters have been synthesised. These included two biotinylated compounds linked either by an aminocaproate or by a cleavable dithiol link. These compounds have been derivatised via a key
