2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

Base Information

Chemical Name:2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid
CAS No.:207971-22-0
Molecular Formula:C₂₀H₂₆F₃N₃O₇
Molecular Weight:477.438
Hs Code.:

Synonyms:2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

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Chemical Property of 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

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Technology Process of 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

There total 3 articles about 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 299931-13-8
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

: 207971-22-0
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

Guidance literature:: With pyridine; tetra-n-butylammonium permanganate; at 20 ℃; for 12h; Darkness;
DOI:10.1016/j.bmc.2010.03.059

Reference yield:

: 205485-25-2
2-methoxy-4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde

: 207971-22-0
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2: 91 percent / K₂CO₃; nBu₄NI / dimethylformamide / 12 h / 60 °C

3: 90 percent / tetrabutylammonium permanganate / pyridine / 2 h / 20 °C

With tetra-n-butylammonium permanganate; boron tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(01)00025-8

Reference yield:

: 308085-25-8
2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

: 207971-22-0
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃; nBu₄NI / dimethylformamide / 12 h / 60 °C

2: 90 percent / tetrabutylammonium permanganate / pyridine / 2 h / 20 °C

With tetra-n-butylammonium permanganate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(01)00025-8